QuickView for GDF7;jsessionid=910A938F17301737C429CF3ADC804AB7 (gene)

Gene Symbol:

GDF7 Homo sapiens

Full name:

growth differentiation factor 7

Synonyms:

BMP12, growth/differentiation factor 7, GDF-7

Genomic Location:

Chr 2: 20729905-20734731

Description:

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subuni...

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This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

STAT1_02 ,  GATA3_01 ,  YATTNATC_UNKNOWN ,  IPF1_Q4 ,  STAT1_03 ,  PBX1_01 ,  SPZ1_01 ,  YCATTAA_UNKNOWN ,  HAND1E47_01 ,  CRX_Q4

Cytogenetic Map:

2p24.1

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