QuickView for GNAO1;jsessionid=71E361B6A21B5712E455C0DB91BE6503 (gene)
- Gene Symbol:
- GNAO1
Homo sapiens - Full name:
- G protein subunit alpha o1
- Synonyms:
- EIEE17, G-ALPHA-o, GNAO, HLA-DQB1, NEDIM, guanine nucleotide-binding protein G(o) subunit alpha, GO2-q chimeric G-protein, guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, guanine nucleotide-binding regulatory protein 2
- Genomic Location:
- Chr 16: 54783649-54948651
- Description:
-
The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Bos taurus , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-103 , Predicted Gene Targets for miR-129 , Predicted Gene Targets for miR-134 , Predicted Gene Targets for miR-139 , Predicted Gene Targets for miR-181 , Predicted Gene Targets for miR-218 , Predicted Gene Targets for miR-30 , Predicted Gene Targets for miR-326 , Predicted Gene Targets for miR-330 , Predicted Gene Targets for miR-539
- Cytogenetic Map:
-
16q13
GO Molecular Function
guanyl ribonucleotide binding | ribonucleoside binding | cation binding | opioid receptor binding | hormone receptor binding | protein-containing complex binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | G-protein coupled serotonin receptor binding | hydrolase activity | G-protein beta/gamma-subunit complex binding | carbohydrate derivative binding | pyrophosphatase activity | neuropeptide receptor binding | catalytic activity | anion binding | nucleoside-triphosphatase activity | purine nucleotide binding | ion binding | organic cyclic compound binding | GTPase activity | purine nucleoside binding | mu-type opioid receptor binding | peptide hormone receptor binding | purine ribonucleoside triphosphate binding | protein binding | GTPase activating protein binding | corticotropin-releasing hormone receptor binding | G-protein coupled receptor binding | GTP binding | hydrolase activity, acting on acid anhydrides | nucleoside binding | purine ribonucleotide binding | corticotropin-releasing hormone receptor 1 binding | metal ion binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | guanyl nucleotide binding | small molecule binding
GO Biological Process
brain development | response to cytokine | regulation of localization | response to isoquinoline alkaloid | cell differentiation | nervous system development | response to drug | neurogenesis | generation of neurons | response to antibiotic | positive regulation of GTPase activity | cellular process | response to morphine | odontogenesis | neuron development | positive regulation of catalytic activity | response to inorganic substance | response to hydrogen peroxide | regulation of cellular process | cellular component organization | head development | muscle contraction | response to stimulus | response to stress | regulation of blood circulation | negative regulation of transport | G-protein coupled receptor signaling pathway | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | response to nitrogen compound | system development | Wnt signaling pathway | multicellular organism development | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | regulation of catalytic activity | animal organ morphogenesis | response to ammonium ion | response to oxidative stress | positive regulation of hydrolase activity | non-canonical Wnt signaling pathway | locomotory behavior | negative regulation of ion transport | response to toxic substance | regulation of GTPase activity | response to xenobiotic stimulus | regulation of heart contraction | dopamine receptor signaling pathway | cell communication | odontogenesis of dentin-containing tooth | negative regulation of calcium ion transport | positive regulation of molecular function | neuron differentiation | Wnt signaling pathway, calcium modulating pathway | response to organic substance | anatomical structure development | cell surface receptor signaling pathway | cell projection organization | behavior | neuron projection development | protein folding | animal organ development | response to reactive oxygen species | forebrain development | response to alkaloid | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | signaling | response to organic cyclic compound | cell development | anatomical structure morphogenesis | regulation of ion transport | developmental process | regulation of calcium ion transport | regulation of transport | response to organonitrogen compound | central nervous system development | response to anesthetic | aging | muscle system process | signal transduction | multicellular organismal process
GO Cellular Component
heterotrimeric G-protein complex | cytoplasmic side of plasma membrane | dendrite | catalytic complex | neuron projection | extrinsic component of membrane | somatodendritic compartment | cell body | cell | cytoplasmic side of membrane | plasma membrane protein complex | extrinsic component of plasma membrane | dendritic tree | protein-containing complex | cell projection | plasma membrane | extrinsic component of cytoplasmic side of plasma membrane | cell periphery | intracellular | myelin sheath | membrane
