QuickView for GPC3 (gene)

Gene Symbol:

GPC3 Homo sapiens

Full name:

glypican 3

Synonyms:

DGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1, glypican-3, glypican proteoglycan 3, heparan sulphate proteoglycan, intestinal protein OCI-5, secreted glypican-3

Genomic Location:

Chr X: 132497439-132947332

Description:

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These prote...

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Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  GATTGGY_NFY_Q6_01 ,  SMTTTTGT_UNKNOWN ,  GCGSCMNTTT_UNKNOWN ,  TFIIA_Q6 ,  TGANTCA_AP1_C ,  DR3_Q4 ,  HOXA4_Q2 ,  MYCMAX_03 ,  CACGTG_MYC_Q2 ,  SMAD3_Q6 ,  NFY_C ,  AAANWWTGC_UNKNOWN ,  YATTNATC_UNKNOWN ,  HP1SITEFACTOR_Q6 ,  LYF1_01 ,  GGGAGGRR_MAZ_Q6 ,  MYCMAX_02 ,  STAT3_02 ,  CAGGTA_AREB6_01 ,  ALPHACP1_01 ,  RFX1_02 ,  MYCMAX_01 ,  GGGCGGR_SP1_Q6 ,  NFY_01 ,  GTGCCAA_MIR96 ,  OCT1_03 ,  POU1F1_Q6 ,  RNGTGGGC_UNKNOWN ,  NCX_01 ,  NMYC_01 ,  EN1_01 ,  OCT1_02 ,  CHX10_01 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  RYTGCNNRGNAAC_MIF1_01 ,  CP2_02 ,  CTGCAGY_UNKNOWN ,  TGACAGNY_MEIS1_01 ,  CTTTGT_LEF1_Q2 ,  CDC5_01 ,  P300_01 ,  GCTNWTTGK_UNKNOWN ,  AACTTT_UNKNOWN ,  PAX2_02 ,  CP2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182

Cytogenetic Map:

Xq26.2

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