QuickView for GPD1 (gene)

Gene Symbol:

GPD1 Homo sapiens

Full name:

glycerol-3-phosphate dehydrogenase 1

Synonyms:

GPD-C, GPDH-C, HTGTI, glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic, glycerol-3-phosphate dehydrogenase 1 (soluble), glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic, glycerophosphate dehydrogenase

Genomic Location:

Chr 12: 48784068-48791363

Description:

This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cy...

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This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Gallus gallus ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E12_Q6 ,  TAL1ALPHAE47_01 ,  TTANTCA_UNKNOWN ,  RYTTCCTG_ETS2_B ,  TGANNYRGCA_TCF11MAFG_01 ,  MYC_Q2 ,  ATGTCAC_MIR489 ,  AML_Q6 ,  CACGTG_MYC_Q2 ,  GCANCTGNY_MYOD_Q6 ,  PEA3_Q6 ,  LYF1_01 ,  HEB_Q6 ,  AML1_01 ,  WTGAAAT_UNKNOWN ,  OSF2_Q6 ,  HNF4_01 ,  CEBPDELTA_Q6 ,  TAL1BETAE47_01 ,  CAGGTG_E12_Q6 ,  GAGCTGG_MIR337 ,  HNF4_Q6 ,  GGGCGGR_SP1_Q6 ,  USF_C ,  TGCCAAR_NF1_Q6 ,  NF1_Q6_01 ,  RACCACAR_AML_Q6 ,  AREB6_03 ,  NMYC_01 ,  AML1_Q6 ,  TAL1BETAITF2_01 ,  GRE_C ,  CAGCTG_AP4_Q5 ,  USF2_Q6 ,  TCCCCAC_MIR491 ,  PPAR_DR1_Q2 ,  COREBINDINGFACTOR_Q6 ,  CP2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-542-3p ,  Predicted Gene Targets for miR-491

Cytogenetic Map:

12q13.12

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