QuickView for GPR153 (gene)

Gene Symbol:

GPR153 Homo sapiens

Full name:

G protein-coupled receptor 153

Synonyms:

PGR1, probable G-protein coupled receptor 153, G-protein coupled receptor PGR1

Genomic Location:

Chr 1: 6231443-6243622

Description:

This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associated with a significant reduction in food intake and impaired decision making ability. Mutation...

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This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associated with a significant reduction in food intake and impaired decision making ability. Mutations in this gene are associated with schizophrenia, autism, and other neuropsychiatric disorders. The expression of this gene is activated by the glioma-associated oncogene homolog 1 transcription factor which, in turn, is activated by sonic hedgehog in normal and tumorigenic cells.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RSRFC4_01 ,  RSRFC4_Q2 ,  CTAWWWATA_RSRFC4_Q2 ,  MEF2_02 ,  TATAAA_TATA_01 ,  STAT_01 ,  TTCYNRGAA_STAT5B_01 ,  STAT5A_01 ,  TBP_01 ,  MMEF2_Q6

Cytogenetic Map:

1p36.31

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