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QuickView for GPS2;jsessionid=DA8418571AF35E1CD8994477639793A5 (gene)


Gene Symbol:
GPS2 Homo sapiens Homo sapiens
Full name:
G protein pathway suppressor 2
Synonyms:
AMF-1, G protein pathway suppressor 2, GPS-2
Genomic Location:
Chr 17: 7156702-7159382
Description:
This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Danio rerio Pan troglodytes Bos taurus Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 17
17p13.1


Transcripts Names
NM_004489
Protein Names
Q6FHM8
Q13227



GO Molecular Function

cyclin binding | enzyme inhibitor activity | GTPase regulator activity | molecular function regulator | transcription corepressor activity | transcription coactivator activity | protein binding | enzyme regulator activity | transcription coregulator activity | GTPase inhibitor activity

GO Biological Process

RNA metabolic process | negative regulation of JNK cascade | negative regulation of phosphorylation | positive regulation of macromolecule biosynthetic process | negative regulation of MAPK cascade | negative regulation of immune system process | intracellular signal transduction | regulation of cholesterol transport | regulation of localization | regulation of immune system process | negative regulation of cellular process | negative regulation of kinase activity | regulation of MAP kinase activity | negative regulation of RNA biosynthetic process | cell differentiation | negative regulation of fat cell differentiation | negative regulation of protein phosphorylation | B cell differentiation | regulation of lipid transport | negative regulation of stress-activated protein kinase signaling cascade | positive regulation of cellular biosynthetic process | cellular process | negative regulation of inflammatory response | lymphocyte differentiation | negative regulation of signaling | positive regulation of cholesterol efflux | immune system development | negative regulation of tumor necrosis factor-mediated signaling pathway | negative regulation of nucleic acid-templated transcription | regulation of response to cytokine stimulus | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of fat cell differentiation | regulation of cell differentiation | interspecies interaction between organisms | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of metabolic process | inactivation of MAPK activity | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | MAPK cascade | negative regulation of toll-like receptor signaling pathway | response to stimulus | enzyme inhibitor activity | JNK cascade | signal transduction by protein phosphorylation | GTPase regulator activity | response to stress | negative regulation of protein kinase activity | cellular nitrogen compound biosynthetic process | regulation of protein ubiquitination | cellular nitrogen compound metabolic process | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | protein modification process | cellular biosynthetic process | macromolecule modification | molecular function regulator | stress-activated protein kinase signaling cascade | regulation of nucleic acid-templated transcription | leukocyte differentiation | regulation of cellular response to stress | system development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of phosphate metabolic process | multicellular organism development | negative regulation of catalytic activity | regulation of toll-like receptor signaling pathway | regulation of MAPK cascade | phosphorus metabolic process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of gene expression | cellular response to stress | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | negative regulation of protein serine/threonine kinase activity | transcription corepressor activity | regulation of transcription by RNA polymerase II | positive regulation of cholesterol transport | B cell activation | biosynthetic process | stress-activated MAPK cascade | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | phosphorylation | negative regulation of stress-activated MAPK cascade | regulation of GTPase activity | positive regulation of lipid localization | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of tumor necrosis factor-mediated signaling pathway | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | regulation of cytokine-mediated signaling pathway | transcription coactivator activity | negative regulation of MAP kinase activity | regulation of RNA metabolic process | negative regulation of protein ubiquitination | positive regulation of transport | viral process | lymphocyte activation | protein metabolic process | regulation of innate immune response | regulation of kinase activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | negative regulation of response to cytokine stimulus | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of protein polyubiquitination | regulation of protein K63-linked ubiquitination | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | positive regulation of peroxisome proliferator activated receptor signaling pathway | negative regulation of cellular protein metabolic process | gene expression | regulation of phosphate metabolic process | transcription, DNA-templated | regulation of JNK cascade | cell activation | negative regulation of protein metabolic process | regulation of stress-activated MAPK cascade | regulation of cell communication | regulation of peroxisome proliferator activated receptor signaling pathway | response to mitochondrial depolarisation | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | cellular protein metabolic process | enzyme regulator activity | cellular macromolecule biosynthetic process | negative regulation of protein K63-linked ubiquitination | regulation of developmental process | regulation of cholesterol efflux | developmental process | cellular protein modification process | negative regulation of transcription by RNA polymerase II | regulation of transport | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | negative regulation of GTPase activity | transcription coregulator activity | regulation of B cell receptor signaling pathway | positive regulation of transcription by RNA polymerase II | negative regulation of cytokine-mediated signaling pathway | heterocycle metabolic process | negative regulation of hydrolase activity | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid transport | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | GTPase inhibitor activity | regulation of inflammatory response | negative regulation of B cell receptor signaling pathway | negative regulation of cell differentiation | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | mitochondrion | membrane-bounded organelle | transcriptional repressor complex | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular