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QuickView for GPX4 (gene)

Gene Symbol:
GPX4 Homo sapiens Homo sapiens
Full name:
glutathione peroxidase 4
GPx-4, GSHPx-4, MCSP, PHGPx, SMDS, snGPx, snPHGPx, phospholipid hydroperoxide glutathione peroxidase, mitochondrial, phospholipid hydroperoxide glutathione peroxidase, phospholipid hydroperoxidase, sperm nucleus glutathione peroxidase
Genomic Location:
Chr 19: 1054936-1057787
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate spe...
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Bos taurus Danio rerio Gallus gallus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 19

GO Molecular Function

peroxidase activity | antioxidant activity | catalytic activity | identical protein binding | selenium binding | protein binding | phospholipid-hydroperoxide glutathione peroxidase activity | glutathione peroxidase activity | oxidoreductase activity, acting on peroxide as acceptor | oxidoreductase activity

GO Biological Process

sulfur compound metabolic process | regulation of programmed cell death | glutathione metabolic process | response to hormone | negative regulation of cellular process | peroxidase activity | male gamete generation | phospholipid metabolic process | cellular process | cellular detoxification | chromatin organization | antioxidant activity | response to estradiol | multicellular organismal reproductive process | gamete generation | regulation of cellular process | cellular component organization | cellular lipid metabolic process | response to stimulus | monocarboxylic acid metabolic process | response to stress | negative regulation of ferroptosis | reproduction | cellular nitrogen compound metabolic process | cellular response to toxic substance | cofactor metabolic process | cellular component assembly | cellular biosynthetic process | nitrogen compound metabolic process | reproductive process | multicellular organism development | phosphorus metabolic process | lipid metabolic process | response to lipid | organophosphate metabolic process | small molecule metabolic process | protein polymerization | cellular amide metabolic process | response to oxidative stress | fatty acid biosynthetic process | biosynthetic process | long-chain fatty acid biosynthetic process | lipid biosynthetic process | cellular protein-containing complex assembly | response to toxic substance | lipoxygenase pathway | phosphate-containing compound metabolic process | peptide metabolic process | long-chain fatty acid metabolic process | carboxylic acid metabolic process | multicellular organism reproduction | protein-containing complex assembly | response to organic substance | phospholipid-hydroperoxide glutathione peroxidase activity | anatomical structure development | metabolic process | cellular oxidant detoxification | oxidation-reduction process | negative regulation of programmed cell death | organic substance metabolic process | fatty acid metabolic process | glutathione peroxidase activity | icosanoid metabolic process | response to organic cyclic compound | organic acid metabolic process | developmental process | organelle organization | spermatogenesis | detoxification | cellular modified amino acid metabolic process | oxidoreductase activity, acting on peroxide as acceptor | chromosome organization | cellular metabolic process | regulation of cell death | oxidoreductase activity | negative regulation of cell death | regulation of inflammatory response | aging | sexual reproduction | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | protein-containing complex | endomembrane system | nucleoplasm | nuclear envelope | vesicle | extracellular exosome | mitochondrion | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | membrane-enclosed lumen | cytosol | intracellular