QuickView for GPX4 (gene)

Gene Symbol:

GPX4 Homo sapiens

Full name:

glutathione peroxidase 4

Synonyms:

GPx-4, GSHPx-4, MCSP, PHGPx, SMDS, snGPx, snPHGPx, phospholipid hydroperoxide glutathione peroxidase, mitochondrial, phospholipid hydroperoxide glutathione peroxidase, phospholipid hydroperoxidase, sperm nucleus glutathione peroxidase

Genomic Location:

Chr 19: 1054936-1057787

Description:

The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate spe...

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The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GGGAGGRR_MAZ_Q6 ,  GGGYGTGNY_UNKNOWN ,  TGCGCANK_UNKNOWN ,  GGGCGGR_SP1_Q6

Cytogenetic Map:

19p13.3

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