QuickView for GRB2 (gene)

Gene Symbol:

GRB2 Homo sapiens

Full name:

growth factor receptor bound protein 2

Synonyms:

ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2, growth factor receptor-bound protein 2, HT027, SH2/SH3 adapter GRB2, abundant SRC homology, epidermal growth factor receptor-binding protein GRB2, growth factor receptor-bound protein 3, protein Ash

Genomic Location:

Chr 17: 70825752-70913385

Description:

The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in th...

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The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E12_Q6 ,  MYOD_Q6_01 ,  PR_02 ,  CTCTATG_MIR368 ,  ATF6_01 ,  PR_01 ,  NGFIC_01 ,  CTATGCA_MIR153 ,  CAGTGTT_MIR141_MIR200A ,  E2A_Q2 ,  ACTGTGA_MIR27A_MIR27B ,  CDPCR3HD_01 ,  ATCATGA_MIR433 ,  GTGACGY_E4F1_Q6 ,  CAGGTG_E12_Q6 ,  CAGCTTT_MIR320 ,  SP1_Q4_01 ,  EGR_Q6 ,  GGGCGGR_SP1_Q6 ,  E47_01 ,  SP1_Q6 ,  GTGCCTT_MIR506 ,  GR_01 ,  SCGGAAGY_ELK1_02 ,  EGR1_01 ,  RCGCANGCGY_NRF1_Q6 ,  SP1_Q6_01 ,  GTTAAAG_MIR302B ,  ELF1_Q6 ,  SP1_Q2_01 ,  TCCAGAG_MIR518C

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-433-3p ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-376c

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Cytogenetic Map:

17q25.1

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