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QuickView for GRIK2 (gene)


Gene Symbol:
GRIK2 Homo sapiens Homo sapiens
Full name:
glutamate ionotropic receptor kainate type subunit 2
Synonyms:
EAA4, GLR6, GLUK6, GLUR6, GluK2, MRT6, glutamate receptor ionotropic, kainate 2, bA487F5.1, excitatory amino acid receptor 4, gluR-6, glutamate receptor 6, glutamate receptor form A, glutamate receptor form B, glutamate receptor form C, glutamate receptor form D, glutamate receptor form E
Genomic Location:
Chr 6: 101953675-102623474
Description:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by th...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 6
6q16.3





GO Molecular Function

transmitter-gated ion channel activity | neurotransmitter receptor activity | passive transmembrane transporter activity | transmembrane signaling receptor activity | enzyme binding | transmembrane transporter activity | ligand-gated ion channel activity | ion gated channel activity | protein domain specific binding | ubiquitin-like protein ligase binding | kainate selective glutamate receptor activity | cation transmembrane transporter activity | ubiquitin conjugating enzyme binding | signaling receptor activity | transporter activity | identical protein binding | ion transmembrane transporter activity | extracellular ligand-gated ion channel activity | glutamate receptor activity | protein binding | protein homodimerization activity | potassium channel activity | ionotropic glutamate receptor activity | ubiquitin protein ligase binding | metal ion transmembrane transporter activity | protein dimerization activity | potassium ion transmembrane transporter activity | ubiquitin-like protein conjugating enzyme binding | excitatory extracellular ligand-gated ion channel activity | extracellularly glutamate-gated ion channel activity | sodium ion transmembrane transporter activity | sodium channel activity | cation channel activity | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | PDZ domain binding | channel activity | ion channel activity | substrate-specific channel activity

GO Biological Process

transmitter-gated ion channel activity | behavioral fear response | positive regulation of apoptotic process | regulation of programmed cell death | establishment of localization | neuron death | negative regulation of neuron death | negative regulation of cellular process | excitatory postsynaptic potential | defense response | cellular chemical homeostasis | intracellular transport | regulation of neuron death | cellular process | localization | cellular homeostasis | positive regulation of synaptic transmission | protein transport | passive transmembrane transporter activity | negative regulation of signaling | metal ion transport | chemical synaptic transmission | regulation of neuronal synaptic plasticity | macromolecule localization | negative regulation of apoptotic process | establishment of localization in cell | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | transmembrane transporter activity | ligand-gated ion channel activity | calcium ion homeostasis | response to stimulus | ion gated channel activity | response to stress | intracellular protein transport | receptor clustering | programmed cell death | cellular localization | neuronal action potential | modulation of chemical synaptic transmission | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | metal ion homeostasis | regulation of membrane potential | regulation of cellular response to stress | negative regulation of neuron apoptotic process | regulation of long-term neuronal synaptic plasticity | apoptotic process | regulation of signal transduction | regulation of synaptic transmission, glutamatergic | regulation of MAPK cascade | regulation of phosphorylation | ion transmembrane transport | localization within membrane | regulation of postsynaptic membrane potential | protein localization to membrane | organic substance transport | nervous system process | synaptic signaling | kainate selective glutamate receptor activity | sodium ion transport | cation transmembrane transporter activity | cellular ion homeostasis | monovalent inorganic cation transport | regulation of nitrogen compound metabolic process | neuron apoptotic process | peptide transport | cellular potassium ion transport | ion transmembrane transporter activity | potassium ion transport | synaptic transmission, glutamatergic | regulation of cellular protein metabolic process | extracellular ligand-gated ion channel activity | positive regulation of neuron death | cation homeostasis | negative regulation of synaptic transmission, glutamatergic | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of neuron apoptotic process | regulation of protein metabolic process | cellular calcium ion homeostasis | homeostatic process | regulation of protein phosphorylation | cation transmembrane transport | potassium channel activity | multicellular organismal response to stress | fear response | inhibitory postsynaptic potential | ionotropic glutamate receptor activity | metal ion transmembrane transporter activity | regulation of intracellular signal transduction | positive regulation of neuron apoptotic process | cell surface receptor signaling pathway | potassium ion transmembrane transporter activity | negative regulation of programmed cell death | cellular protein localization | amide transport | chemical homeostasis | behavior | positive regulation of cell death | sodium ion transmembrane transport | cell death | excitatory extracellular ligand-gated ion channel activity | extracellularly glutamate-gated ion channel activity | positive regulation of programmed cell death | ion homeostasis | sodium ion transmembrane transporter activity | regulation of phosphate metabolic process | inorganic cation transmembrane transport | sodium channel activity | establishment of protein localization | regulation of JNK cascade | cation channel activity | regulation of stress-activated MAPK cascade | regulation of cell communication | transmembrane transport | action potential | signaling | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | protein localization | cation transport | cellular macromolecule localization | channel activity | glutamate receptor signaling pathway | behavioral defense response | potassium ion transmembrane transport | cellular metal ion homeostasis | transmission of nerve impulse | negative regulation of synaptic transmission | ion channel activity | regulation of synaptic plasticity | ion transport | regulation of cell death | negative regulation of cell death | ionotropic glutamate receptor signaling pathway | regulation of short-term neuronal synaptic plasticity | divalent inorganic cation homeostasis | substrate-specific channel activity | positive regulation of signaling | signal transduction | regulation of signaling | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

presynaptic membrane | integral component of membrane | dendrite | synapse | neuron projection | potassium channel complex | somatodendritic compartment | cell body | cell | neuronal cell body | plasma membrane protein complex | distal axon | intrinsic component of membrane | synaptic membrane | terminal bouton | cytoplasm | dendrite cytoplasm | receptor complex | dendritic tree | presynapse | protein-containing complex | cell projection | postsynaptic membrane | postsynapse | plasma membrane bounded cell projection cytoplasm | plasma membrane | perikaryon | kainate selective glutamate receptor complex | postsynaptic density | asymmetric synapse | cytoplasmic region | integral component of plasma membrane | organelle | postsynaptic specialization | axon terminus | sodium channel complex | cell periphery | axon | ionotropic glutamate receptor complex | transmembrane transporter complex | neuron projection terminus | cation channel complex | ion channel complex | intracellular | cell junction | membrane | intrinsic component of plasma membrane