QuickView for GRIN1;jsessionid=E7B5DB9477979439F1C8BE0276B24088 (gene)

Gene Symbol:

GRIN1 Homo sapiens

Full name:

glutamate ionotropic receptor NMDA type subunit 1

Synonyms:

GluN1, MRD8, NMD-R1, NMDA1, NMDAR1, NR1, glutamate receptor ionotropic, NMDA 1, N-methyl-D-aspartate receptor channel, subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1, glutamate [NMDA] receptor subunit zeta-1, glutamate receptor, ionotropic, N-methyl D-aspartate 1

Genomic Location:

Chr 9: 139153430-139183029

Description:

The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory...

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The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  MYOD_Q6_01 ,  NGFIC_01 ,  E2A_Q2 ,  NRSF_01 ,  GGGAGGRR_MAZ_Q6 ,  TGAYRTCA_ATF3_Q6 ,  GTGTGAG_MIR342 ,  CAGGTG_E12_Q6 ,  CAGNWMCNNNGAC_UNKNOWN ,  CCTGCTG_MIR214 ,  GTGGTGA_MIR197 ,  CAGCCTC_MIR4855P ,  CTTTGT_LEF1_Q2 ,  EGR1_01 ,  YNGTTNNNATT_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  LMO2COM_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-485-5p

Cytogenetic Map:

9q34.3

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