QuickView for GRIN2A (gene)

Gene Symbol:

GRIN2A Homo sapiens

Full name:

glutamate ionotropic receptor NMDA type subunit 2A

Synonyms:

EPND, FESD, GluN2A, LKS, NMDAR2A, NR2A, glutamate receptor ionotropic, NMDA 2A, N-methyl D-aspartate receptor subtype 2A, N-methyl-D-aspartate receptor channel, subunit epsilon-1, N-methyl-D-aspartate receptor subunit 2A, glutamate receptor, ionotropic, N-methyl D-aspartate 2A

Genomic Location:

Chr 16: 9762923-10184112

Description:

This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie ce...

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This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without cognitive disability. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

POU6F1_01 ,  SP1_01 ,  TTTGCAC_MIR19A_MIR19B ,  GATA1_01 ,  TTANTCA_UNKNOWN ,  P53_DECAMER_Q2 ,  CACGTG_MYC_Q2 ,  GCANCTGNY_MYOD_Q6 ,  VDR_Q6 ,  HNF1_C ,  AAGCAAT_MIR137 ,  WHN_B ,  LFA1_Q6 ,  P53_02 ,  CAGGTG_E12_Q6 ,  CTCAGGG_MIR125B_MIR125A ,  SP1_Q4_01 ,  SP3_Q3 ,  GGGCGGR_SP1_Q6 ,  USF_C ,  E2F1_Q3_01 ,  S8_01 ,  SP1_Q6 ,  GATA2_01 ,  RNGTGGGC_UNKNOWN ,  MYB_Q6 ,  NMYC_01 ,  AP2REP_01 ,  CTGCAGY_UNKNOWN ,  YRCCAKNNGNCGC_UNKNOWN ,  HIF1_Q3 ,  HNF6_Q6 ,  PAX4_01 ,  SP1_Q2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-431 ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-137

Cytogenetic Map:

16p13.2

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