QuickView for GRK2 (gene)

Gene Symbol:

GRK2 Homo sapiens

Full name:

G protein-coupled receptor kinase 2

Synonyms:

ADRBK1, BARK1, BETA-ARK1, beta-adrenergic receptor kinase 1, adrenergic beta receptor kinase 1, beta-ARK-1

Genomic Location:

Chr 11: 66790481-66810605

Description:

This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for...

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This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  NFAT_Q6 ,  HOXA4_Q2 ,  PEA3_Q6 ,  WGTTNNNNNAAA_UNKNOWN ,  CTTTGA_LEF1_Q2 ,  TGAYRTCA_ATF3_Q6 ,  CEBPDELTA_Q6 ,  LEF1_Q2 ,  CAGGTG_E12_Q6 ,  TTCYRGAA_UNKNOWN ,  AP4_Q6 ,  AP4_01 ,  MYB_Q6 ,  AATGTGA_MIR23A_MIR23B ,  CAGCTG_AP4_Q5 ,  AACTTT_UNKNOWN ,  AP4_Q5

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-323

Cytogenetic Map:

11q13.2

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