QuickView for GRM6;jsessionid=FF1B71614589EB5FF8FDB16E9373CE78 (gene)

Gene Symbol:

GRM6 Homo sapiens

Full name:

glutamate metabotropic receptor 6

Synonyms:

CSNB1B, GPRC1F, MGLUR6, mGlu6, metabotropic glutamate receptor 6, glutamate receptor, metabotropic 6

Genomic Location:

Chr 5: 178337934-178354730

Description:

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G pr...

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L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GGGAGGRR_MAZ_Q6 ,  GGATTA_PITX2_Q2 ,  MEIS1_01 ,  SREBP_Q3 ,  TGACAGNY_MEIS1_01

Cytogenetic Map:

5q35.3

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