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QuickView for GRP78 (gene)


Gene Symbol:
HSPA5 Homo sapiens Homo sapiens
Full name:
heat shock protein family A (Hsp70) member 5
Synonyms:
BIP, GRP78, HEL-S-89n, MIF2, 78 kDa glucose-regulated protein, endoplasmic reticulum lumenal Ca(2+)-binding protein grp78, epididymis secretory sperm binding protein Li 89n, glucose-regulated protein, 78kDa, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa), immunoglobulin heavy chain-binding protein
Genomic Location:
Chr 9: 127036953-127043430
Description:
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Danio rerio Gallus gallus Bos taurus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 9
9q33.3


Transcripts Names
NM_005347



GO Molecular Function

cadherin binding | cation binding | enzyme binding | protein-containing complex binding | ribonucleotide binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | unfolded protein binding | ATPase activity | pyrophosphatase activity | catalytic activity | chaperone binding | ribonucleoprotein complex binding | protein domain specific binding | ATP binding | ubiquitin-like protein ligase binding | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | ATPase activity, coupled | purine nucleotide binding | ion binding | organic cyclic compound binding | ribosome binding | protein binding involved in protein folding | cell adhesion molecule binding | purine ribonucleoside triphosphate binding | protein binding | misfolded protein binding | ubiquitin protein ligase binding | hydrolase activity, acting on acid anhydrides | calcium ion binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | heat shock protein binding | metal ion binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding

GO Biological Process

response to extracellular stimulus | brain development | response to radiation | regulation of IRE1-mediated unfolded protein response | cellular response to glucose starvation | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | response to nutrient levels | response to endoplasmic reticulum stress | response to cytokine | positive regulation of cellular component organization | regulation of ATF6-mediated unfolded protein response | regulation of neurogenesis | 'de novo' posttranslational protein folding | regulation of endoplasmic reticulum unfolded protein response | proteolysis | regulation of cell development | regulation of localization | regulation of programmed cell death | establishment of localization | regulation of transforming growth factor beta receptor signaling pathway | neuron death | negative regulation of cellular process | negative regulation of IRE1-mediated unfolded protein response | positive regulation of developmental process | response to metal ion | cell differentiation | nervous system development | cellular response to extracellular stimulus | response to drug | ATF6-mediated unfolded protein response | cerebellum morphogenesis | neurogenesis | positive regulation of cellular component movement | generation of neurons | response to antibiotic | PERK-mediated unfolded protein response | response to organophosphorus | response to methamphetamine hydrochloride | positive regulation of cellular biosynthetic process | cellular process | organic substance catabolic process | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | regulation of cell motility | localization | negative regulation of protein homodimerization activity | proteolysis involved in cellular protein catabolic process | chaperone-mediated protein folding | negative regulation of signaling | protein localization to endoplasmic reticulum | macromolecule localization | endoplasmic reticulum unfolded protein response | negative regulation of response to endoplasmic reticulum stress | negative regulation of apoptotic process | cellular response to starvation | response to growth factor | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | response to inorganic substance | regulation of binding | regulation of cell differentiation | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | response to nerve growth factor | positive regulation of cellular protein metabolic process | cellular response to unfolded protein | cellular response to organonitrogen compound | response to topologically incorrect protein | cellular response to topologically incorrect protein | cellular response to metal ion | anatomical structure arrangement | head development | response to stimulus | metencephalon development | positive regulation of protein metabolic process | response to cocaine | response to stress | regulation of response to endoplasmic reticulum stress | toxin transport | protein folding in endoplasmic reticulum | regulation of protein ubiquitination | response to starvation | regulation of protein homodimerization activity | programmed cell death | cellular response to inorganic substance | cellular protein catabolic process | cellular localization | response to temperature stimulus | midbrain development | proteasomal protein catabolic process | maintenance of protein localization in organelle | negative regulation of endoplasmic reticulum unfolded protein response | cellular response to organic cyclic compound | positive regulation of RNA biosynthetic process | regulation of PERK-mediated unfolded protein response | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of nucleic acid-templated transcription | negative regulation of cellular response to transforming growth factor beta stimulus | regulation of cellular response to stress | response to nitrogen compound | apoptotic process | system development | cellular response to nutrient levels | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of neuron projection development | cellular response to antibiotic | multicellular organism development | response to purine-containing compound | cerebellum development | cellular response to nerve growth factor stimulus | ER-nucleus signaling pathway | regulation of neuron differentiation | regulation of gene expression | cellular response to stress | protein catabolic process | stress response to metal ion | cellular response to heat | positive regulation of cellular metabolic process | cellular response to radiation | response to manganese ion | response to ammonium ion | regulation of nitrogen compound metabolic process | regulation of cell migration | neuron apoptotic process | positive regulation of cell projection organization | negative regulation of cellular response to growth factor stimulus | substantia nigra development | regulation of cellular component movement | regulation of transcription by RNA polymerase II | cellular response to gamma radiation | protein localization to organelle | negative regulation of binding | positive regulation of cell differentiation | positive regulation of cell migration | cellular response to cytokine stimulus | 'de novo' protein folding | regulation of cellular protein metabolic process | positive regulation of transcription from RNA polymerase II promoter in response to stress | hindbrain development | response to xenobiotic stimulus | response to gamma radiation | cellular response to drug | maintenance of protein location | cell communication | negative regulation of protein binding | regulation of cellular metabolic process | regulation of protein metabolic process | protein binding involved in protein folding | regulation of locomotion | regulation of RNA metabolic process | regulation of cellular response to growth factor stimulus | proteasome-mediated ubiquitin-dependent protein catabolic process | ER overload response | ERAD pathway | neuron differentiation | cellular response to interleukin-4 | protein metabolic process | negative regulation of transforming growth factor beta receptor signaling pathway | positive regulation of protein modification process | cellular response to calcium ion | response to organic substance | cellular macromolecule catabolic process | IRE1-mediated unfolded protein response | anatomical structure development | positive regulation of neurogenesis | metabolic process | positive regulation of cell development | regulation of DNA-templated transcription in response to stress | regulation of RNA biosynthetic process | negative regulation of programmed cell death | cellular protein localization | cerebellar cortex development | hindbrain morphogenesis | organic substance metabolic process | protein folding | cell death | cerebellar Purkinje cell layer development | maintenance of protein localization in endoplasmic reticulum | animal organ development | cerebellum structural organization | response to heat | cellular response to ionizing radiation | maintenance of protein location in cell | cellular response to cAMP | response to alkaloid | hindbrain structural organization | response to cAMP | ubiquitin-dependent protein catabolic process | organonitrogen compound catabolic process | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of protein folding in endoplasmic reticulum | regulation of transcription, DNA-templated | regulation of protein binding | response to organic cyclic compound | protein localization | cellular protein metabolic process | regulation of transcription from RNA polymerase II promoter in response to stress | response to unfolded protein | anatomical structure morphogenesis | cellular macromolecule localization | response to biotic stimulus | chaperone cofactor-dependent protein refolding | regulation of nervous system development | regulation of developmental process | developmental process | response to salt | cellular response to manganese ion | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | protein refolding | response to calcium ion | central nervous system development | ubiquitin-dependent ERAD pathway | response to anesthetic | positive regulation of metabolic process | positive regulation of neuron differentiation | regulation of cell projection organization | cellular metabolic process | cellular response to organic substance | regulation of cell death | positive regulation of cell motility | modification-dependent protein catabolic process | negative regulation of cell death | positive regulation of protein ubiquitination | regulation of cellular component organization | response to ionizing radiation | neural nucleus development | signal transduction | regulation of signaling | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | maintenance of location in cell | multicellular organismal process | response to interleukin-4

GO Cellular Component

endoplasmic reticulum chaperone complex | endoplasmic reticulum-Golgi intermediate compartment | integral component of membrane | intracellular membrane-bounded organelle | adherens junction | focal adhesion | cytoplasmic vesicle | COP9 signalosome | cell | integral component of endoplasmic reticulum membrane | smooth endoplasmic reticulum | intrinsic component of membrane | cytoplasm | cell-substrate junction | intracellular organelle | intrinsic component of endoplasmic reticulum membrane | endoplasmic reticulum | melanosome | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | endomembrane system | endoplasmic reticulum membrane | plasma membrane | midbody | vesicle | endoplasmic reticulum lumen | extracellular exosome | mitochondrion | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | cell periphery | membrane-enclosed lumen | cell-substrate adherens junction | intracellular vesicle | cell surface | intracellular | cell junction | myelin sheath | membrane