QuickView for GRs (gene)

Gene Symbol:

BCL2A1 Homo sapiens

Full name:

BCL2 related protein A1

Synonyms:

ACC-1, ACC-2, ACC1, ACC2, BCL2L5, BFL1, GRS, HBPA1, bcl-2-related protein A1, bcl-2-like protein 5, bcl2-L-5, hematopoietic BCL2-related protein A1, hemopoietic-specific early response protein, protein BFL-1

Genomic Location:

Chr 15: 78040290-78050698

Description:

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-ap...

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This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

EGR2_01 ,  AACTTT_UNKNOWN

Cytogenetic Map:

15q25.1

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