QuickView for GSKIP (gene)
- Gene Symbol:
- GSKIP
Homo sapiens - Full name:
- GSK3B interacting protein
- Synonyms:
- C14orf129, HSPC210, GSK3B-interacting protein, GSK3-beta interaction protein
- Genomic Location:
- Chr 14: 95915775-95923321
- Description:
-
This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein con...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
14q32.2
GO Molecular Function
beta-catenin binding | protein kinase regulator activity | kinase regulator activity | protein kinase inhibitor activity | enzyme inhibitor activity | molecular function regulator | protein kinase A binding | protein kinase A regulatory subunit binding | protein binding | kinase inhibitor activity | enzyme regulator activity
GO Biological Process
negative regulation of phosphorylation | intracellular signal transduction | protein kinase regulator activity | negative regulation of cellular process | negative regulation of kinase activity | negative regulation of protein phosphorylation | cellular process | kinase regulator activity | protein kinase inhibitor activity | regulation of canonical Wnt signaling pathway | negative regulation of cellular metabolic process | intrinsic apoptotic signaling pathway | regulation of cellular process | regulation of metabolic process | response to stimulus | enzyme inhibitor activity | response to stress | negative regulation of protein kinase activity | programmed cell death | negative regulation of metabolic process | molecular function regulator | apoptotic process | regulation of signal transduction | negative regulation of phosphate metabolic process | negative regulation of catalytic activity | regulation of catalytic activity | cellular response to oxidative stress | regulation of phosphorylation | cellular response to stress | regulation of nitrogen compound metabolic process | response to oxidative stress | regulation of cellular protein metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | apoptotic signaling pathway | intrinsic apoptotic signaling pathway in response to oxidative stress | kinase inhibitor activity | regulation of kinase activity | cell death | negative regulation of cellular protein metabolic process | regulation of Wnt signaling pathway | regulation of phosphate metabolic process | positive regulation of canonical Wnt signaling pathway | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of molecular function | signaling | enzyme regulator activity | cell death in response to oxidative stress | positive regulation of Wnt signaling pathway | positive regulation of signaling | signal transduction | regulation of signaling | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | membrane-bounded organelle | nucleus | organelle | intracellular
