QuickView for GSR (gene)

Gene Symbol:

GSR Homo sapiens

Full name:

glutathione-disulfide reductase

Synonyms:

HEL-75, HEL-S-122m, glutathione reductase, mitochondrial, GR, GRase, epididymis luminal protein 75, epididymis secretory sperm binding protein Li 122m, glutathione S-reductase

Genomic Location:

Chr 8: 30655977-30704985

Description:

This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result...

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This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AP3_Q6 ,  TTGCWCAAY_CEBPB_02 ,  AR_Q6

Cytogenetic Map:

8p12

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