QuickView for GSTM2 (gene)

Gene Symbol:

GSTM2 Homo sapiens

Full name:

glutathione S-transferase mu 2

Synonyms:

GST4, GSTM, GSTM2-2, GTHMUS, glutathione S-transferase Mu 2, GST class-mu 2, GST, muscle, S-(hydroxyalkyl)glutathione lyase M2, glutathione S-alkyltransferase M2, glutathione S-aralkyltransferase M2, glutathione S-aryltransferase M2, glutathione S-transferase 4, glutathione S-transferase M1, glutathione S-transferase M2 (muscle), glutathione S-transferase mu 2 (muscle)

Genomic Location:

Chr 1: 110012214-110019431

Description:

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the...

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Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Pan troglodytes

External Links:

Entrez Gene

Cytogenetic Map:

1p13.3

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