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QuickView for GSTO1 (gene)


Gene Symbol:
GSTO1 Homo sapiens Homo sapiens
Full name:
glutathione S-transferase omega 1
Synonyms:
GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R, glutathione S-transferase omega-1, MMA(V) reductase, S-(Phenacyl)glutathione reductase, epididymis secretory protein Li 21, glutathione S-transferase omega 1-1, glutathione-S-transferase like, glutathione-dependent dehydroascorbate reductase, monomethylarsonic acid reductase
Genomic Location:
Chr 10: 106004668-106017203
Description:
The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding diffe...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Gallus gallus Danio rerio Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Cytogenetic Map:
chr 10
10q25.1





GO Molecular Function

glutathione transferase activity | antioxidant activity | transferase activity, transferring alkyl or aryl (other than methyl) groups | catalytic activity | glutathione dehydrogenase (ascorbate) activity | oxidoreductase activity, acting on a sulfur group of donors | glutathione disulfide oxidoreductase activity | disulfide oxidoreductase activity | protein binding | methylarsonate reductase activity | transferase activity | peptide disulfide oxidoreductase activity | oxidoreductase activity

GO Biological Process

positive regulation of release of sequestered calcium ion into cytosol | regulation of muscle system process | response to cytokine | positive regulation of ion transmembrane transporter activity | regulation of cellular localization | intracellular signal transduction | regulation of localization | sulfur compound metabolic process | regulation of skeletal muscle contraction by calcium ion signaling | negative regulation of cellular process | cellular chemical homeostasis | xenobiotic catabolic process | positive regulation of cation channel activity | glutathione derivative biosynthetic process | cellular process | cellular homeostasis | cellular detoxification | regulation of calcium-mediated signaling | antioxidant activity | negative regulation of signaling | regulation of cellular process | xenobiotic metabolic process | positive regulation of ryanodine-sensitive calcium-release channel activity | catabolic process | regulation of cytosolic calcium ion concentration | negative regulation of calcium-mediated signaling | calcium ion homeostasis | response to stimulus | cellular response to xenobiotic stimulus | positive regulation of cation transmembrane transport | regulation of cardiac muscle contraction by calcium ion signaling | regulation of blood circulation | negative regulation of transporter activity | cellular response to toxic substance | negative regulation of transport | cofactor metabolic process | cellular biosynthetic process | response to interleukin-12 | interleukin-12-mediated signaling pathway | negative regulation of calcium ion transmembrane transport | negative regulation of transmembrane transport | metal ion homeostasis | regulation of calcium ion transport into cytosol | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of calcium ion transmembrane transport | regulation of muscle contraction | glutathione dehydrogenase (ascorbate) activity | oxidoreductase activity, acting on a sulfur group of donors | methylation | cellular ion homeostasis | glutathione disulfide oxidoreductase activity | positive regulation of ion transmembrane transport | positive regulation of cytosolic calcium ion concentration | monosaccharide metabolic process | small molecule metabolic process | negative regulation of release of sequestered calcium ion into cytosol | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion | second-messenger-mediated signaling | positive regulation of calcium-mediated signaling | regulation of release of sequestered calcium ion into cytosol | negative regulation of ion transmembrane transport | cellular response to cytokine stimulus | negative regulation of calcium ion transmembrane transporter activity | biosynthetic process | negative regulation of ion transport | carbohydrate metabolic process | regulation of calcium ion transmembrane transport | response to toxic substance | response to xenobiotic stimulus | regulation of heart contraction | cation homeostasis | regulation of striated muscle contraction | cellular cation homeostasis | cell communication | L-ascorbic acid metabolic process | negative regulation of cation channel activity | positive regulation of transporter activity | positive regulation of sequestering of calcium ion | negative regulation of calcium ion transport | regulation of cardiac muscle contraction | positive regulation of signal transduction | cellular calcium ion homeostasis | homeostatic process | positive regulation of transport | negative regulation of calcium ion transport into cytosol | disulfide oxidoreductase activity | carboxylic acid metabolic process | positive regulation of molecular function | calcium-mediated signaling | regulation of ryanodine-sensitive calcium-release channel activity | response to organic substance | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | methylarsonate reductase activity | vitamin metabolic process | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cell surface receptor signaling pathway | metabolic process | cellular response to arsenic-containing substance | cellular oxidant detoxification | oxidation-reduction process | positive regulation of striated muscle contraction | chemical homeostasis | positive regulation of muscle contraction | negative regulation of ion transmembrane transporter activity | organic substance metabolic process | regulation of sequestering of calcium ion | positive regulation of ion transport | ion homeostasis | positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion | regulation of ion transmembrane transport | regulation of skeletal muscle contraction | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | response to arsenic-containing substance | signaling | positive regulation of calcium ion transmembrane transporter activity | regulation of transmembrane transporter activity | organic acid metabolic process | regulation of ion transmembrane transporter activity | positive regulation of calcium ion transport into cytosol | regulation of ion transport | peptide disulfide oxidoreductase activity | negative regulation of ryanodine-sensitive calcium-release channel activity | regulation of calcium ion transport | regulation of transport | detoxification | regulation of cation channel activity | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | cellular metal ion homeostasis | regulation of calcium ion transmembrane transporter activity | cellular metabolic process | cellular response to organic substance | oxidoreductase activity | divalent inorganic cation homeostasis | positive regulation of calcium ion transport | positive regulation of signaling | signal transduction | regulation of signaling

GO Cellular Component

cell | cytoplasm | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cytosol | intracellular