QuickView for GTF2I (gene)

Gene Symbol:

GTF2I Homo sapiens

Full name:

general transcription factor IIi

Synonyms:

BAP135, BTKAP1, DIWS, GTFII-I, IB291, SPIN, TFII-I, WBS, WBSCR6, general transcription factor II-I, BTK-associated protein, 135kD, Bruton tyrosine kinase-associated protein 135, SRF-Phox1-interacting protein, Williams-Beuren syndrome chromosome region 6

Genomic Location:

Chr 7: 73709966-73812958

Description:

This gene encodes a phosphoprotein containing six characteristic repeat motifs. The encoded protein binds to the initiator element (Inr) and E-box element in promoters and functions as a regulator of transcription. This locus, along with several other neighboring genes, is deleted in Williams-Beuren syndrome. There are many closely related genes an...

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This gene encodes a phosphoprotein containing six characteristic repeat motifs. The encoded protein binds to the initiator element (Inr) and E-box element in promoters and functions as a regulator of transcription. This locus, along with several other neighboring genes, is deleted in Williams-Beuren syndrome. There are many closely related genes and pseudogenes for this gene on chromosome 7. This gene also has pseudogenes on chromosomes 9, 13, and 21. Alternatively spliced transcript variants encoding multiple isoforms have been observed.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTTGTAT_MIR381 ,  GATTGGY_NFY_Q6_01 ,  NFY_C ,  HNF4_DR1_Q3 ,  CAGGTG_E12_Q6 ,  GGGCGGR_SP1_Q6 ,  NFY_01 ,  YGCGYRCGC_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  CCATCCA_MIR432 ,  HNF4_01_B

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-381

Cytogenetic Map:

7q11.23

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