QuickView for GYPB (gene)

Gene Symbol:

GYPB Homo sapiens

Full name:

glycophorin B (MNS blood group)

Synonyms:

CD235b, GPB, GYP, MNS, PAS-3, SS, glycophorin-B, GYPB-A fusion, GYPB-A-B fusion, GYPB/GYPA fusion, SS-active sialoglycoprotein, Ss blood group, blood group system MNSs, Mur-like, blood group system MNSs, St(a) type E, blood group system MNSs, St(a) type F, glycophorin B blood group antigen, glycophorin B, blood group system Ss, S, Mit+, glycophorin B/glycophorin A fusion protein, glycophorin Hop, hybrid glycophorin Kip, sialoglycoprotein delta

Genomic Location:

Chr 4: 145136707-145159946

Description:

Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s a...

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Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants.

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Orthologs:

Macaca mulatta

External Links:

Entrez Gene

Cytogenetic Map:

4q31.21

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