QuickView for Gdnf (gene)

Gene Symbol:

GDNF Homo sapiens

Full name:

glial cell derived neurotrophic factor

Synonyms:

ATF, ATF1, ATF2, HFB1-GDNF, HSCR3, glial cell line-derived neurotrophic factor, astrocyte-derived trophic factor

Genomic Location:

Chr 5: 37851510-37875539

Description:

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subuni...

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This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  RTAAACA_FREAC2_01 ,  HNF4ALPHA_Q6 ,  AP1_C ,  AGCYRWTTC_UNKNOWN ,  TGANTCA_AP1_C ,  ATF6_01 ,  RYTTCCTG_ETS2_B ,  AREB6_02 ,  FOX_Q2 ,  PR_01 ,  YATGNWAAT_OCT_C ,  IPF1_Q4 ,  FXR_IR1_Q6 ,  FAC1_01 ,  CTTTGA_LEF1_Q2 ,  HNF4_DR1_Q3 ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01 ,  GTGACGY_E4F1_Q6 ,  CAGGTG_E12_Q6 ,  AP1_01 ,  DR1_Q3 ,  GR_Q6 ,  BACH2_01 ,  ATF3_Q6 ,  GGGCGGR_SP1_Q6 ,  PITX2_Q2 ,  RAAGNYNNCTTY_UNKNOWN ,  CTTTAAR_UNKNOWN ,  GCCNNNWTAAR_UNKNOWN ,  BACH1_01 ,  GR_01 ,  ATF1_Q6 ,  AAAYRNCTG_UNKNOWN ,  IRF7_01 ,  COUP_DR1_Q6 ,  TGATTTRY_GFI1_01 ,  WCAANNNYCAG_UNKNOWN ,  CAGCTG_AP4_Q5 ,  SMAD_Q6 ,  P300_01 ,  BRN2_01 ,  DR4_Q2 ,  AP1_Q4_01

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Cytogenetic Map:

5p13.2

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