QuickView for Glisoxepide (compound)

1-(Hexahydro-1H-azepin-1-yl)-3-((p-(2-(5-methyl-3-isoxazolecarboxamido)ethyl)phenyl)sulfonyl)urea; EINECS 246-579-5; Glisoxepida [INN-Spanish]; Glisoxepid; 3-Isoxazolecarboxamide, N-(2-(4-(((((hexahydro-1H-azepin-1-yl)amino)carbonyl)amino)sulfonyl)phenyl)ethyl)-5-methyl-; BRN 0592109; Glisoxepida [Spanish]; Bay B 4231; Glisoxepidum [INN-Latin]; BS 4231.
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1-(Hexahydro-1H-azepin-1-yl)-3-((p-(2-(5-methyl-3-isoxazolecarboxamido)ethyl)phenyl)sulfonyl)urea; EINECS 246-579-5; Glisoxepida [INN-Spanish]; Glisoxepid; 3-Isoxazolecarboxamide, N-(2-(4-(((((hexahydro-1H-azepin-1-yl)amino)carbonyl)amino)sulfonyl)phenyl)ethyl)-5-methyl-; BRN 0592109; Glisoxepida [Spanish]; Bay B 4231; Glisoxepidum [INN-Latin]; BS 4231; Pro-Diaban; Glisoxepide Glisoxepid; RP 22410; 3-ISOXAZOLECARBOXAMIDE, N-(2-(4-(((((HEXAHYDRO-1H-AZEPIN-1-YL)AMINO)CARBONYL)AMI; Glisoxepide; Glisepin; Glisoxepide [BAN:DCF:INN]; 25046-79-1; FBB 4231
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Glisoxepide is a hypoglycemic sulphonylurea agent. The sulphonylureas are a family of drugs based on a common sulphonylurea core. These drugs act via augmentation of secretion of insulin from pancreatic beta-cells. Sulphonylureas may also cause a reduction in serum glucagon and potentiate the action of insulin at the extrapancreatic tissues. Gliso...
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Glisoxepide is a hypoglycemic sulphonylurea agent. The sulphonylureas are a family of drugs based on a common sulphonylurea core. These drugs act via augmentation of secretion of insulin from pancreatic beta-cells. Sulphonylureas may also cause a reduction in serum glucagon and potentiate the action of insulin at the extrapancreatic tissues. Glisoxepide functions as a non-selective K(ATP) channel blocker. It is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) (K(ATP)) channels (Kir6.2/SUR1 complex, KATP channels) in pancreatic beta-cells. This inhibits a tonic, hyperpolarizing efflux of potassium, thus causing the electric potential over the membrane to become more positive. This depolarization opens voltage-gated Ca2+ channels. The rise in intracellular calcium leads to increased fusion of insulin granulae with the cell membrane, and therefore increased secretion of (pro)insulin.
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