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QuickView for Glycodiazine (compound)

Name: glymidine
PubChem Compound ID: 9565
Molecular formula: C13H15N3O4S
Molecular weight: 309.342 g/mol
Glymidinum; GLYMIDINE; 5-25-12-00549 (Beilstein Handbook Reference); 5-beta-(Methoxyethoxy)-2-(phenylsulfonylamido)pyrimidine; BRN 0552655; EINECS 206-426-5; Glycodiazine Glymidine; 339-44-6; Benzenesulfonamide, N-(5-(2-methoxyethoxy)-2-pyrimidinyl)-; 2-Benzolsulfonamido-5-beta-methoxy-aethoxy-pyrimidine [German].
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Name: glymidine
Name (isomeric): DB01382
Drug Type: small molecule
Glidiazine; Glymidine
Category: Hypoglycemic Agents
CAS number: 339-44-6
Indication: Glycodiazine is used concomitantly with insulin for the treatment of noninsulin-dependent (type 2) diabetes mellitus.
Pharmacology: Glycodiazine is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and increasing the sensitivity of peripheral tissues to insulin.
Mechanism of Action:
The mechanism of action of glycodiazine in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells, and increasing sensitivity of peripheral tissues to insulin. Glycodiazine likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium...
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Absorption: Rapidly and completely absorbed following oral administration.
Protein binding: 90% bound to plasma proteins.
Half Life: 4 hours.
Toxicity: Severe hypoglycemic reactions with coma, seizure, or other neurological impairment.
Affected organisms: Humans and other mammals
Drug interaction:
PindololThe beta-blocker, pindolol, may decrease symptoms of hypoglycemia.
ChloramphenicolChloramphenicol may increase the effect of sulfonylurea, glycodiazine.
RifampinRifampin may decrease the effect of sulfonylurea, glycodiazine.
ClofibrateClofibrate may increase the effect of sulfonylurea, glycodiazine.
OxprenololThe beta-blocker, oxprenolol, may decrease symptoms of hypoglycemia.
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