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QuickView for Grem1 (gene)


Gene Symbol:
GREM1 Homo sapiens Homo sapiens
Full name:
gremlin 1, DAN family BMP antagonist
Synonyms:
C15DUPq, CKTSF1B1, CRAC1, CRCS4, DAND2, DRM, DUP15q, GREMLIN, HMPS, HMPS1, IHG-2, MPSH, PIG2, gremlin-1, DAN domain family member 2, cell proliferation-inducing gene 2 protein, colorectal adenoma and carcinoma 1, cysteine knot superfamily 1, BMP antagonist 1, down-regulated in Mos-transformed cells protein, gremlin 1, cysteine knot superfamily, homolog, gremlin 1-like protein, increased in high glucose-2
Genomic Location:
Chr 15: 30797497-30814158
Description:
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonist...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 15
15q13.3





GO Molecular Function

protein kinase activator activity | cytokine binding | enzyme activator activity | protein kinase regulator activity | BMP binding | kinase regulator activity | signaling receptor binding | protein tyrosine kinase activator activity | cytokine receptor binding | molecular function regulator | identical protein binding | vascular endothelial growth factor receptor binding | vascular endothelial growth factor receptor 2 binding | protein binding | protein homodimerization activity | receptor regulator activity | protein dimerization activity | kinase activator activity | receptor ligand activity | cytokine activity | enzyme regulator activity | growth factor receptor binding | morphogen activity | transmembrane receptor protein tyrosine kinase activator activity | receptor activator activity

GO Biological Process

regulation of leukocyte chemotaxis | negative regulation of phosphorylation | limb development | positive regulation of striated muscle cell differentiation | cell morphogenesis | protein kinase activator activity | nephron tubule formation | positive regulation of macromolecule biosynthetic process | negative regulation of immune system process | extracellular structure organization | positive regulation of cellular component organization | cell motility | mesonephric tubule formation | intracellular signal transduction | enzyme activator activity | regulation of localization | protein kinase regulator activity | morphogenesis of an epithelium | positive regulation of DNA-binding transcription factor activity | positive regulation of striated muscle tissue development | regulation of programmed cell death | negative regulation of bone development | regulation of cardiac muscle cell differentiation | positive regulation of peptidyl-tyrosine phosphorylation | regulation of osteoblast proliferation | blood vessel endothelial cell migration | regulation of immune system process | negative regulation of BMP signaling pathway | negative regulation of cellular process | positive regulation of developmental process | negative regulation of RNA biosynthetic process | embryonic appendage morphogenesis | cell differentiation | negative regulation of tissue remodeling | positive regulation of signaling receptor activity | ureteric bud formation | negative regulation of protein phosphorylation | epithelial cell migration | positive regulation of phosphate metabolic process | blood vessel morphogenesis | regulation of bone remodeling | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation | regulation of cell motility | localization | epithelial tube morphogenesis | limb morphogenesis | negative regulation of signaling | positive regulation of transcription from RNA polymerase II promoter involved in heart development | kinase regulator activity | epithelium migration | positive regulation of telomerase activity | negative regulation of nucleic acid-templated transcription | renal tubule morphogenesis | regulation of striated muscle tissue development | positive regulation of protein kinase activity | regulation of chemotaxis | negative regulation of apoptotic process | branching involved in ureteric bud morphogenesis | regulation of monocyte chemotaxis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | regulation of canonical Wnt signaling pathway | negative regulation of cellular metabolic process | regulation of bone mineralization | tissue development | regulation of cell differentiation | metanephric nephron development | positive regulation of muscle cell differentiation | muscle structure development | negative regulation of osteoclast proliferation | negative regulation of cell motility | regulation of angiogenesis | regulation of cellular process | regulation of osteoblast differentiation | regulation of apoptotic process | regulation of metabolic process | metanephric nephron morphogenesis | negative regulation of chemotaxis | positive regulation of cellular protein metabolic process | epithelium development | cellular component organization | urogenital system development | negative regulation of biomineral tissue development | nephron tubule morphogenesis | sprouting angiogenesis | regulation of vasculature development | response to stimulus | vasculature development | positive regulation of NIK/NF-kappaB signaling | embryonic limb morphogenesis | regulation of peptidyl-tyrosine phosphorylation | embryonic epithelial tube formation | activation of transmembrane receptor protein tyrosine kinase activity | positive regulation of protein metabolic process | endothelial cell migration | regulation of receptor internalization | protein tyrosine kinase activator activity | regulation of cell proliferation | tube morphogenesis | programmed cell death | supramolecular fiber organization | epithelial tube formation | negative regulation of leukocyte chemotaxis | cardiovascular system development | extracellular matrix organization | metanephros morphogenesis | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | regulation of cell adhesion | dorsal/ventral pattern formation | kidney development | embryo development | regulation of morphogenesis of a branching structure | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | cell-cell signaling | activation of protein kinase activity | molecular function regulator | blood vessel development | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | locomotion | negative regulation of osteoblast differentiation | apoptotic process | negative regulation of bone mineralization involved in bone maturation | regulation of protein tyrosine kinase activity | system development | regulation of signal transduction | ureteric bud development | negative regulation of growth | negative regulation of phosphate metabolic process | regulation of adherens junction organization | regulation of cartilage development | multicellular organism development | cell migration | regulation of MAPK cascade | regulation of BMP signaling pathway | positive regulation of muscle organ development | regulation of catalytic activity | regulation of phosphorylation | kidney morphogenesis | regulation of ossification | regulation of receptor-mediated endocytosis | positive regulation of receptor-mediated endocytosis | determination of bilateral symmetry | regulation of gene expression | kidney epithelium development | regulation of protein autophosphorylation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of telomerase activity | animal organ morphogenesis | negative regulation of chondrocyte differentiation | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cell-substrate adhesion | enzyme linked receptor protein signaling pathway | negative regulation of cellular response to growth factor stimulus | positive regulation of intracellular signal transduction | cardiocyte differentiation | regulation of cellular component movement | regulation of transcription by RNA polymerase II | positive regulation of cell differentiation | stem cell differentiation | renal vesicle morphogenesis | regulation of cellular protein metabolic process | cell differentiation involved in kidney development | angiogenesis | mesonephric epithelium development | cellular protein-containing complex assembly | mesenchymal to epithelial transition involved in metanephros morphogenesis | positive regulation of peptidyl-tyrosine autophosphorylation | mesonephros development | mesenchymal to epithelial transition | regulation of leukocyte migration | proximal/distal pattern formation | negative regulation of bone trabecula formation | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | metanephros development | renal tubule development | cell differentiation involved in metanephros development | positive regulation of DNA biosynthetic process | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | positive regulation of signal transduction | heart development | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | regulation of RNA metabolic process | renal system development | positive regulation of transport | negative regulation of cell growth | regulation of cellular response to growth factor stimulus | embryonic morphogenesis | nephron development | positive regulation of molecular function | regulation of signaling receptor activity | receptor regulator activity | negative regulation of branching involved in ureteric bud morphogenesis | protein-containing complex assembly | ureteric bud morphogenesis | regionalization | positive regulation of protein modification process | regulation of growth | regulation of cardiac muscle tissue development | tissue morphogenesis | negative regulation of bone mineralization | branching morphogenesis of an epithelial tube | regulation of kinase activity | regulation of animal organ morphogenesis | negative regulation of pathway-restricted SMAD protein phosphorylation | negative regulation of ossification | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | regulation of bone development | regulation of focal adhesion assembly | anatomical structure development | kinase activator activity | cell surface receptor signaling pathway | metanephric renal vesicle morphogenesis | positive regulation of branching involved in ureteric bud morphogenesis | negative regulation of leukocyte proliferation | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | regulation of tissue remodeling | regulation of vesicle-mediated transport | morphogenesis of embryonic epithelium | receptor ligand activity | regulation of chondrocyte differentiation | cytokine activity | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | nephron morphogenesis | animal organ development | negative regulation of cellular protein metabolic process | negative regulation of cellular component movement | positive regulation of NF-kappaB transcription factor activity | positive regulation of kinase activity | regulation of Wnt signaling pathway | regulation of striated muscle cell differentiation | regulation of phosphate metabolic process | positive regulation of muscle tissue development | morphogenesis of a branching epithelium | anatomical structure formation involved in morphogenesis | negative regulation of cartilage development | negative regulation of protein metabolic process | positive regulation of cardiac muscle cell differentiation | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of signal transduction | signaling | negative regulation of monocyte chemotaxis | regulation of transcription, DNA-templated | myoblast differentiation | regulation of endocytosis | negative regulation of osteoblast proliferation | determination of dorsal identity | collagen fibril organization | positive regulation of phosphorylation | positive regulation of protein tyrosine kinase activity | enzyme regulator activity | cardioblast differentiation | morphogenesis of a branching structure | anatomical structure morphogenesis | positive regulation of receptor internalization | negative regulation of leukocyte migration | regulation of developmental process | renal vesicle development | positive regulation of DNA metabolic process | developmental process | negative regulation of canonical Wnt signaling pathway | regulation of muscle cell differentiation | regulation of DNA biosynthetic process | regulation of cell growth | positive regulation of protein autophosphorylation | tube development | regulation of cell junction assembly | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | cardiac muscle cell myoblast differentiation | cell migration involved in sprouting angiogenesis | positive regulation of kidney development | positive regulation of nucleic acid-templated transcription | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | regulation of epithelial to mesenchymal transition | tube formation | regulation of branching involved in ureteric bud morphogenesis | regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation | negative regulation of bone remodeling | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | negative regulation of Wnt signaling pathway | ameboidal-type cell migration | regulation of cell death | positive regulation of cardiac muscle tissue development | morphogen activity | signal transduction by p53 class mediator | transmembrane receptor protein tyrosine kinase activator activity | negative regulation of cell death | circulatory system development | negative regulation of locomotion | receptor activator activity | positive regulation of endocytosis | positive regulation of angiogenesis | nephron tubule development | negative regulation of cell differentiation | regulation of cellular component organization | determination of dorsal/ventral asymmetry | positive regulation of signaling | signal transduction | regulation of signaling | mesonephric tubule development | regulation of pathway-restricted SMAD protein phosphorylation | positive regulation of gene expression | negative regulation of mononuclear cell migration | regulation of cell-matrix adhesion | regulation of muscle organ development | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

cell | extracellular region | extracellular space | cell surface | intracellular