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QuickView for Guanabenz (compound)


PubChem
Name: Guanabenz
PubChem Compound ID: 3517
Description: An alpha-2 selective adrenergic agonist used as an antihypertensive agent.
Molecular formula: C8H8Cl2N4
Molecular weight: 231.081 g/mol
Synonyms:
Prestwick1_000096; Prestwick0_000096; NINDS_000010; DivK1c_000010; Spectrum3_000445; Spectrum2_001114; KBio1_000010; KBio2_006459; Spectrum4_000567; SPBio_001991.
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DrugBank
Identification
Name: Guanabenz
Name (isomeric): DB00629
Drug Type: small molecule
Description: An alpha-2 selective adrenergic agonist used as an antihypertensive agent.
Brand: Wy 8678 base, Guanabenzo [INN-Spanish], Wytensin, GBZ, Guanabenz Acetate, Guanabenz [USAN:INN], Guanabenz(USAN), Guanabenzum [INN-Latin]
Category: Sympatholytics, Adrenergic alpha-Agonists, Antihypertensive Agents
CAS number: 5051-62-7
Pharmacology
Indication: For management of High blood pressure
Pharmacology: Guanabenz, a centrally acting α-2 adrenergic agonist, is indicated for treatment of hypertension.
Mechanism of Action:
Guanabenz's antihypertensive effect is thought to be due to central alpha-adrenergic stimulation, which results in a decreased sympathetic outflow to the heart, kidneys, and peripheral vasculature in addition to a decreased systolic and diastolic blood pressure and a slight slowing of pulse rate. Chronic administration of guanabenz also causes a de...
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Absorption: Approximately 75% absorbed from gastrointestinal tract
Protein binding: 90%
Biotransformation: Hepatic
Half Life: 6 hours.
Toxicity: Excessive contraction of the pupils, irritability, low blood pressure, sleepiness, slow heartbeat, sluggishness
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
TrimipramineTrimipramine may reduce the antihypertensive effect of the alpha2-agonist, Guanabenz. Trimipramine may also increase the rebound hypertensive effect of Clonidine. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Clonidine if Trimipramine is initiated, discontinued or dose changed. Guanabenz should be withdrawn very gradually to reduce the risk of hypertensive crisis.
ThiabendazoleThe strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Guanabenz by decreasing Guanabenz metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Guanabenz if Thiabendazole is initiated, discontinued or dose changed.
TreprostinilAdditive hypotensive effect. Monitor antihypertensive therapy during concomitant use.

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