QuickView for H2AFX;jsessionid=CD74FC213603C0F981022153C60E95B5 (gene)

Gene Symbol:

H2AFX Homo sapiens

Full name:

H2A histone family member X

Synonyms:

H2A.X, H2A/X, H2AX, histone H2AX, H2AX histone, histone H2A.x

Genomic Location:

Chr 11: 118469794-118471387

Description:

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linke...

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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  HOXA4_Q2 ,  SRF_Q6 ,  FOXD3_01 ,  AACTGGA_MIR145 ,  E2F_01 ,  TATA_C ,  HNF4_Q6 ,  SRF_Q4 ,  FOXO1_01 ,  CTTTAAR_UNKNOWN ,  GCCNNNWTAAR_UNKNOWN ,  AGGGCCA_MIR328 ,  ARGGGTTAA_UNKNOWN ,  CTGAGCC_MIR24 ,  SRF_Q5_01 ,  AAAGGAT_MIR501 ,  ACAWYAAAG_UNKNOWN ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-328

Cytogenetic Map:

11q23.3

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