QuickView for HAT1 (gene)

Gene Symbol:

HAT1 Homo sapiens

Full name:

histone acetyltransferase 1

Synonyms:

KAT1, histone acetyltransferase type B catalytic subunit

Genomic Location:

Chr 2: 172487204-172556846

Description:

The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependen...

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The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HNF4ALPHA_Q6 ,  MIF1_01 ,  RFX1_01 ,  GGGAGGRR_MAZ_Q6 ,  TTCYRGAA_UNKNOWN ,  GGGCGGR_SP1_Q6 ,  MGGAAGTG_GABP_B ,  ATACTGT_MIR144 ,  ELK1_01 ,  SCGGAAGY_ELK1_02 ,  ELK1_02 ,  AACTTT_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-381

Cytogenetic Map:

2q31.1

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