QuickView for HBB (gene)

Gene Symbol:

HBB Homo sapiens

Full name:

hemoglobin subunit beta

Synonyms:

CD113t-C, beta-globin, hemoglobin subunit beta, beta globin chain, hemoglobin, beta

Genomic Location:

Chr 11: 5203272-5204877

Description:

The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin...

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The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01

Cytogenetic Map:

11p15.4

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