QuickView for HDAC1 (gene)

Gene Symbol:

HDAC1 Homo sapiens

Full name:

histone deacetylase 1

Synonyms:

GON-10, HD1, RPD3, RPD3L1, histone deacetylase 1, reduced potassium dependency, yeast homolog-like 1

Genomic Location:

Chr 1: 32530295-32571811

Description:

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and th...

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Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Danio rerio ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Bos taurus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  MAZ_Q6 ,  TTTTGAG_MIR373 ,  NFY_C ,  CTTTGTA_MIR524 ,  GGGAGGRR_MAZ_Q6 ,  NFY_Q6_01 ,  GGGCGGR_SP1_Q6 ,  NFY_Q6 ,  GGGTGGRR_PAX4_03 ,  SF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-410

Cytogenetic Map:

1p35.2-p35.1

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