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QuickView for HDAC3 (gene)


Gene Symbol:
HDAC3 Homo sapiens Homo sapiens
Full name:
histone deacetylase 3
Synonyms:
HD3, RPD3, RPD3-2, histone deacetylase 3, SMAP45
Genomic Location:
Chr 5: 140980627-140996607
Description:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and rep...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Danio rerio Gallus gallus Bos taurus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 5
5q31.3





GO Molecular Function

NF-kappaB binding | cyclin binding | histone deacetylase activity (H3-K14 specific) | enzyme binding | NAD-dependent histone deacetylase activity (H3-K14 specific) | hydrolase activity | protein deacetylase activity | catalytic activity | chromatin binding | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | NAD-dependent protein deacetylase activity | histone deacetylase activity | transcription corepressor activity | NAD-dependent histone deacetylase activity | protein binding | transcription factor binding | deacetylase activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | histone deacetylase binding | transcription coregulator activity

GO Biological Process

RNA metabolic process | negative regulation of JNK cascade | negative regulation of phosphorylation | positive regulation of macromolecule biosynthetic process | regulation of intracellular protein transport | negative regulation of MAPK cascade | regulation of cellular localization | regulation of localization | regulation of programmed cell death | negative regulation of cellular process | negative regulation of RNA biosynthetic process | histone modification | microtubule cytoskeleton organization | regulation of protein import | negative regulation of protein phosphorylation | histone deacetylation | positive regulation of phosphate metabolic process | microtubule-based process | negative regulation of stress-activated protein kinase signaling cascade | positive regulation of cellular biosynthetic process | cellular process | chromatin organization | negative regulation of signaling | negative regulation of nucleic acid-templated transcription | negative regulation of apoptotic process | positive regulation of nitrogen compound metabolic process | histone deacetylase activity (H3-K14 specific) | spindle assembly | negative regulation of cellular metabolic process | regulation of cell differentiation | regulation of myotube differentiation | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | response to stimulus | regulation of cellular protein localization | positive regulation of cold-induced thermogenesis | positive regulation of protein metabolic process | negative regulation of striated muscle cell differentiation | NAD-dependent histone deacetylase activity (H3-K14 specific) | response to stress | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | circadian rhythm | rhythmic process | cellular nitrogen compound metabolic process | regulation of protein transport | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | protein modification process | protein deacetylase activity | regulation of peptide transport | cellular biosynthetic process | macromolecule modification | histone H3 deacetylation | regulation of TOR signaling | regulation of intracellular transport | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | organelle assembly | nitrogen compound metabolic process | regulation of signal transduction | regulation of protein stability | negative regulation of phosphate metabolic process | NAD-dependent protein deacetylase activity | regulation of MAPK cascade | regulation of phosphorylation | regulation of gene expression | histone deacetylase activity | cellular response to stress | cell cycle | positive regulation of intracellular protein transport | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | cellular response to fluid shear stress | transcription corepressor activity | regulation of transcription by RNA polymerase II | positive regulation of protein localization to nucleus | biosynthetic process | protein deacetylation | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | negative regulation of stress-activated MAPK cascade | negative regulation of myotube differentiation | NAD-dependent histone deacetylase activity | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of TOR signaling | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of RNA metabolic process | positive regulation of transport | regulation of nucleocytoplasmic transport | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of protein import into nucleus | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | negative regulation of cellular protein metabolic process | gene expression | regulation of striated muscle cell differentiation | regulation of phosphate metabolic process | cytoskeleton organization | transcription, DNA-templated | positive regulation of intracellular transport | regulation of JNK cascade | positive regulation of protein transport | negative regulation of protein metabolic process | response to fluid shear stress | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of signal transduction | covalent chromatin modification | regulation of transcription, DNA-templated | positive regulation of phosphorylation | cellular protein metabolic process | cellular macromolecule biosynthetic process | positive regulation of protein import into nucleus | regulation of developmental process | organelle organization | regulation of muscle cell differentiation | positive regulation of protein import | cellular protein modification process | negative regulation of transcription by RNA polymerase II | regulation of transport | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | negative regulation of muscle cell differentiation | regulation of lipid metabolic process | positive regulation of metabolic process | chromosome organization | cellular metabolic process | regulation of protein localization | regulation of cell death | negative regulation of cell death | spindle organization | positive regulation of nucleocytoplasmic transport | negative regulation of cell differentiation | positive regulation of signaling | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | regulation of phosphorus metabolic process

GO Cellular Component

supramolecular fiber | intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | microtubule | cytoplasm | spindle | intracellular organelle | Golgi apparatus | protein-containing complex | endomembrane system | histone deacetylase complex | nucleoplasm | plasma membrane | microtubule cytoskeleton | spindle microtubule | membrane-bounded organelle | transcriptional repressor complex | nucleus | organelle | cell periphery | membrane-enclosed lumen | cytosol | cytoskeleton | intracellular | membrane | supramolecular complex