QuickView for HDAC4 (gene)

Gene Symbol:

HDAC4 Homo sapiens

Full name:

histone deacetylase 4

Synonyms:

AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, histone deacetylase 4, histone deacetylase A

Genomic Location:

Chr 2: 239634801-239987580

Description:

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylas...

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Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  IRF1_01 ,  TTTGCAC_MIR19A_MIR19B ,  TTTGCAG_MIR518A2 ,  HOXA4_Q2 ,  YTATTTTNR_MEF2_02 ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  LXR_DR4_Q3 ,  TTTGTAG_MIR520D ,  CEBP_Q2_01 ,  CAGTGTT_MIR141_MIR200A ,  GTAAACC_MIR2995P ,  GGGCATT_MIR365 ,  WHN_B ,  TAAWWATAG_RSRFC4_Q2 ,  GGGAGGRR_MAZ_Q6 ,  HNF4_01 ,  AGCATTA_MIR155 ,  CEBP_Q2 ,  RGAANNTTC_HSF1_01 ,  TGTATGA_MIR4853P ,  ACATTCC_MIR1_MIR206 ,  CAGGTA_AREB6_01 ,  CEBP_01 ,  RFX1_02 ,  CACCAGC_MIR138 ,  AP4_Q6 ,  CAGCTTT_MIR320 ,  TGCCTTA_MIR124A ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  CDPCR3_01 ,  TAATAAT_MIR126 ,  CAGCAGG_MIR370 ,  GTGCCTT_MIR506 ,  GGCAGCT_MIR22 ,  AACATTC_MIR4093P ,  IK2_01 ,  ICSBP_Q6 ,  CAGCTG_AP4_Q5 ,  ISRE_01 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  AAACCAC_MIR140 ,  AACTTT_UNKNOWN ,  AP4_Q5 ,  PPAR_DR1_Q2 ,  DR4_Q2 ,  STTTCRNTTT_IRF_Q6 ,  GTTRYCATRR_UNKNOWN ,  IRF2_01 ,  MEF2_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-10 ,  Predicted Gene Targets for miR-122a ,  Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-365 ,  Predicted Gene Targets for miR-370 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-140 ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-409-3p ,  Predicted Gene Targets for miR-455 ,  Predicted Gene Targets for miR-485-3p

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miRNA binding sites
(Source: miRecords):

mmu-miR-140 Targeted Genes

Cytogenetic Map:

2q37.3

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