QuickView for HDAC5;jsessionid=A87C5064490A7C1F982001C17B80E9AA (gene)
- Gene Symbol:
- HDAC5
Homo sapiens - Full name:
- histone deacetylase 5
- Synonyms:
- HD5, NY-CO-9, histone deacetylase 5, antigen NY-CO-9
- Genomic Location:
- Chr 17: 39509647-39556540
- Description:
-
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase a...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
17q21.31
GO Molecular Function
sequence-specific DNA binding | kinase binding | transcription regulatory region DNA binding | cation binding | repressing transcription factor binding | protein kinase binding | histone deacetylase activity (H3-K14 specific) | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | NAD-dependent histone deacetylase activity (H3-K14 specific) | hydrolase activity | protein deacetylase activity | catalytic activity | chromatin binding | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | protein kinase C binding | NAD-dependent protein deacetylase activity | histone deacetylase activity | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | ion binding | organic cyclic compound binding | NAD-dependent histone deacetylase activity | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcription factor binding | RNA polymerase II transcription factor binding | RNA polymerase II regulatory region sequence-specific DNA binding | deacetylase activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | histone deacetylase binding | metal ion binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | positive regulation of macromolecule biosynthetic process | response to lipopolysaccharide | regulation of localization | positive regulation of DNA-binding transcription factor activity | response to hormone | negative regulation of cellular process | negative regulation of cell migration involved in sprouting angiogenesis | negative regulation of RNA biosynthetic process | histone modification | cell differentiation | defense response | nervous system development | response to drug | regulation of sprouting angiogenesis | histone deacetylation | neurogenesis | regulation of organelle organization | generation of neurons | B cell differentiation | positive regulation of cellular biosynthetic process | cellular process | regulation of gene expression, epigenetic | lymphocyte differentiation | regulation of cell motility | chromatin organization | immune system development | negative regulation of nucleic acid-templated transcription | regulation of histone modification | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | histone deacetylase activity (H3-K14 specific) | negative regulation of cellular metabolic process | response to peptide hormone | regulation of binding | regulation of histone H3-K9 acetylation | regulation of cell differentiation | regulation of myotube differentiation | negative regulation of cell motility | regulation of angiogenesis | regulation of cellular process | leukocyte activation | cellular response to lipid | gene silencing | regulation of metabolic process | cellular response to molecule of bacterial origin | organic cyclic compound metabolic process | RNA biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | cellular component organization | regulation of vasculature development | response to stimulus | negative regulation of striated muscle cell differentiation | NAD-dependent histone deacetylase activity (H3-K14 specific) | response to cocaine | response to stress | cellular nitrogen compound biosynthetic process | negative regulation of angiogenesis | response to peptide | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | protein modification process | protein deacetylase activity | cellular biosynthetic process | macromolecule modification | histone H3 deacetylation | regulation of nucleic acid-templated transcription | leukocyte differentiation | response to nitrogen compound | cellular response to hormone stimulus | response to external biotic stimulus | system development | nitrogen compound metabolic process | multicellular organism development | NAD-dependent protein deacetylase activity | response to activity | cellular response to peptide hormone stimulus | cellular response to insulin stimulus | regulation of gene expression | histone deacetylase activity | response to lipid | cellular response to peptide | negative regulation of gene expression, epigenetic | positive regulation of cellular metabolic process | response to ammonium ion | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cellular component movement | regulation of transcription by RNA polymerase II | regulation of cell migration involved in sprouting angiogenesis | regulation of endothelial cell migration | B cell activation | negative regulation of epithelial cell migration | biosynthetic process | protein deacetylation | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | response to xenobiotic stimulus | negative regulation of myotube differentiation | NAD-dependent histone deacetylase activity | response to bacterium | negative regulation of blood vessel endothelial cell migration | regulation of cellular metabolic process | chromatin remodeling | inflammatory response | regulation of protein metabolic process | regulation of locomotion | regulation of RNA metabolic process | negative regulation of sprouting angiogenesis | lymphocyte activation | positive regulation of molecular function | neuron differentiation | protein metabolic process | response to organic substance | regulation of DNA-binding transcription factor activity | response to insulin | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | negative regulation of cellular component movement | regulation of striated muscle cell differentiation | regulation of chromosome organization | response to alkaloid | transcription, DNA-templated | cell activation | regulation of epithelial cell migration | regulation of blood vessel endothelial cell migration | covalent chromatin modification | regulation of transcription, DNA-templated | regulation of protein binding | response to organic cyclic compound | cellular protein metabolic process | cellular macromolecule biosynthetic process | response to biotic stimulus | regulation of developmental process | developmental process | organelle organization | regulation of muscle cell differentiation | cellular protein modification process | regulation of histone acetylation | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | negative regulation of vasculature development | positive regulation of nucleic acid-templated transcription | negative regulation of endothelial cell migration | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | negative regulation of muscle cell differentiation | response to anesthetic | positive regulation of metabolic process | chromosome organization | chromatin silencing | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | negative regulation of locomotion | negative regulation of cell differentiation | regulation of cellular component organization | response to other organism | positive regulation of gene expression | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process | regulation of chromatin organization
GO Cellular Component
intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | cytoplasm | intracellular organelle | nuclear body | Golgi apparatus | protein-containing complex | endomembrane system | histone deacetylase complex | nucleoplasm | nuclear speck | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular
