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QuickView for HDAC8 (gene)


Gene Symbol:
HDAC8 Homo sapiens Homo sapiens
Full name:
histone deacetylase 8
Synonyms:
CDA07, CDLS5, HD8, HDACL1, MRXS6, RPD3, WTS, histone deacetylase 8, histone deacetylase-like 1
Genomic Location:
Chr X: 71466091-71709378
Description:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine r...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr X
Xq13.1





GO Molecular Function

cation binding | histone deacetylase activity (H3-K14 specific) | NAD-dependent histone deacetylase activity (H3-K14 specific) | hydrolase activity | protein deacetylase activity | catalytic activity | chromatin binding | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | Hsp70 protein binding | NAD-dependent protein deacetylase activity | histone deacetylase activity | ion binding | NAD-dependent histone deacetylase activity | protein binding | transcription factor binding | Hsp90 protein binding | deacetylase activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | heat shock protein binding | metal ion binding

GO Biological Process

RNA metabolic process | regulation of cell cycle process | regulation of cellular localization | regulation of localization | negative regulation of cellular process | negative regulation of RNA biosynthetic process | histone modification | response to drug | histone deacetylation | regulation of organelle organization | response to antibiotic | regulation of chromosome segregation | cellular process | chromatin organization | negative regulation of nucleic acid-templated transcription | regulation of histone modification | regulation of cell cycle | histone deacetylase activity (H3-K14 specific) | negative regulation of peptidyl-lysine acetylation | negative regulation of cellular metabolic process | regulation of binding | regulation of histone H3-K9 acetylation | regulation of cell differentiation | regulation of cellular process | regulation of osteoblast differentiation | cellular response to lipid | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | cellular component organization | response to stimulus | regulation of cellular protein localization | chromosome segregation | NAD-dependent histone deacetylase activity (H3-K14 specific) | cellular nitrogen compound biosynthetic process | regulation of protein ubiquitination | response to alcohol | cellular nitrogen compound metabolic process | regulation of DNA binding | cellular response to organic cyclic compound | negative regulation of metabolic process | protein modification process | protein deacetylase activity | cellular biosynthetic process | macromolecule modification | histone H3 deacetylation | cellular response to forskolin | regulation of nucleic acid-templated transcription | response to nitrogen compound | negative regulation of osteoblast differentiation | nitrogen compound metabolic process | regulation of protein stability | cellular response to antibiotic | NAD-dependent protein deacetylase activity | sister chromatid segregation | regulation of telomere maintenance | regulation of ossification | regulation of gene expression | histone deacetylase activity | response to ketone | response to lipid | cell cycle | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | regulation of cohesin loading | biosynthetic process | protein deacetylation | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | NAD-dependent histone deacetylase activity | cellular response to drug | nuclear chromosome segregation | regulation of cellular metabolic process | regulation of protein metabolic process | negative regulation of histone H3-K9 acetylation | regulation of RNA metabolic process | negative regulation of protein ubiquitination | regulation of sister chromatid cohesion | protein metabolic process | response to organic substance | negative regulation of ossification | chromatin assembly or disassembly | regulation of sister chromatid segregation | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of histone acetylation | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | negative regulation of cellular protein metabolic process | gene expression | regulation of chromosome organization | transcription, DNA-templated | regulation of protein localization to chromatin | negative regulation of protein metabolic process | negative regulation of chromosome organization | covalent chromatin modification | regulation of transcription, DNA-templated | response to organic cyclic compound | cellular protein metabolic process | cellular macromolecule biosynthetic process | regulation of developmental process | organelle organization | sister chromatid cohesion | cellular protein modification process | cellular response to trichostatin A | regulation of histone acetylation | negative regulation of transcription by RNA polymerase II | negative regulation of protein acetylation | response to organonitrogen compound | heterocycle metabolic process | chromosome organization | cellular metabolic process | cellular response to organic substance | regulation of protein localization | negative regulation of cell differentiation | regulation of cellular component organization | macromolecule metabolic process | regulation of chromatin organization

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | cytoplasm | intracellular organelle | protein-containing complex | histone deacetylase complex | nucleoplasm | plasma membrane | nuclear chromosome | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | intracellular | membrane