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QuickView for HELLS;jsessionid=409E800FC57E543BD115E74F6D15117A (gene)


Gene Symbol:
HELLS Homo sapiens Homo sapiens
Full name:
helicase, lymphoid specific
Synonyms:
ICF4, LSH, Nbla10143, PASG, SMARCA6, lymphoid-specific helicase, SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 6, proliferation-associated SNF2-like protein
Genomic Location:
Chr 10: 96295564-96351846
Description:
This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants encoding different...
Orthologs:
Mus musculus Rattus norvegicus Saccharomyces cerevisiae Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 10
10q23.33





GO Molecular Function

ribonucleotide binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | pyrophosphatase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | hydrolase activity, acting on acid anhydrides | purine ribonucleotide binding | adenyl ribonucleotide binding | helicase activity | drug binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding

GO Biological Process

RNA metabolic process | negative regulation of cellular process | negative regulation of RNA biosynthetic process | cellular process | regulation of gene expression, epigenetic | chromatin organization | negative regulation of nucleic acid-templated transcription | negative regulation of cellular metabolic process | regulation of cellular process | leukocyte activation | gene silencing | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | mononuclear cell proliferation | pericentric heterochromatin assembly | cellular nitrogen compound biosynthetic process | protein-DNA complex assembly | cellular nitrogen compound metabolic process | negative regulation of metabolic process | cellular component assembly | cellular biosynthetic process | macromolecule modification | regulation of nucleic acid-templated transcription | heterochromatin organization | nitrogen compound metabolic process | multicellular organism development | regulation of gene expression | centromere complex assembly | cell cycle | negative regulation of gene expression, epigenetic | regulation of nitrogen compound metabolic process | cell proliferation | leukocyte proliferation | biosynthetic process | cell division | aromatic compound biosynthetic process | cellular protein-containing complex assembly | regulation of cellular metabolic process | chromatin remodeling | regulation of RNA metabolic process | lymphocyte activation | protein-containing complex assembly | DNA metabolic process | chromatin assembly or disassembly | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | DNA packaging | transcription, DNA-templated | maintenance of DNA methylation | cell activation | chromatin assembly | methylation-dependent chromatin silencing | lymphocyte proliferation | covalent chromatin modification | regulation of transcription, DNA-templated | cellular macromolecule biosynthetic process | developmental process | organelle organization | DNA conformation change | heterocycle metabolic process | chromosome organization | chromatin silencing | chromatin remodeling at centromere | immune system process | cellular metabolic process | heterochromatin assembly | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | chromosome, centromeric region | cell | intracellular organelle | chromatin | pericentric heterochromatin | membrane-bounded organelle | heterochromatin | nucleus | organelle | intracellular