QuickView for HELZ;jsessionid=0D9678E35C2B6DA45CC5B3FC6E3569B0 (gene)
- Gene Symbol:
- HELZ
Homo sapiens - Full name:
- helicase with zinc finger
- Synonyms:
- DHRC, DRHC, HUMORF5, probable helicase with zinc finger domain, down-regulated in human cancers protein, helicase with zinc finger domain
- Genomic Location:
- Chr 17: 62497016-62671781
- Description:
-
HELZ is a member of the superfamily I class of RNA helicases. RNA helicases alter the conformation of RNA by unwinding double-stranded regions, thereby altering the biologic activity of the RNA molecule and regulating access to other proteins (Wagner et al., 1999 [PubMed 10471385]).
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
17q24.2
GO Molecular Function
cation binding | nucleic acid binding | ribonucleotide binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | pyrophosphatase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | hydrolase activity, acting on acid anhydrides | purine ribonucleotide binding | adenyl ribonucleotide binding | helicase activity | drug binding | metal ion binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding | RNA binding
GO Biological Process
gene silencing by RNA | cellular process | regulation of gene expression, epigenetic | gene silencing | regulation of metabolic process | posttranscriptional regulation of gene expression | negative regulation of metabolic process | regulation of gene expression | posttranscriptional gene silencing | posttranscriptional gene silencing by RNA | negative regulation of gene expression
GO Cellular Component
pole plasm | intracellular membrane-bounded organelle | cell | ribonucleoprotein granule | cytoplasm | P granule | intracellular organelle | germ plasm | protein-containing complex | ribonucleoprotein complex | membrane-bounded organelle | nucleus | organelle | cytoplasmic ribonucleoprotein granule | cytosol | intracellular | membrane
