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QuickView for HERC5 (gene)


Gene Symbol:
HERC5 Homo sapiens Homo sapiens
Full name:
HECT and RLD domain containing E3 ubiquitin protein ligase 5
Synonyms:
CEB1, CEBP1, E3 ISG15--protein ligase HERC5, HECT domain and RCC1-like domain-containing protein 5, cyclin-E-binding protein 1, hect domain and RLD 5, probable E3 ubiquitin-protein ligase HERC5
Genomic Location:
Chr 4: 89597291-89646337
Description:
This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylat...
Orthologs:
Macaca mulatta Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Cytogenetic Map:
chr 4
4q22.1


Transcripts Names
NM_016323
XM_011532022
Protein Names
Q9UII4
B2RTQ1
Q69G20
B4DXV3



GO Molecular Function

nucleic acid binding | catalytic activity | ubiquitin-like protein transferase activity | ISG15 transferase activity | organic cyclic compound binding | protein binding | ubiquitin-protein transferase activity | transferase activity | heterocyclic compound binding | RNA binding

GO Biological Process

response to virus | negative regulation of type I interferon production | defense response to other organism | regulation of immune system process | defense response | cellular process | regulation of defense response to virus | regulation of cell cycle | regulation of cellular process | regulation of metabolic process | regulation of type I interferon production | response to stimulus | response to stress | protein modification process | macromolecule modification | response to external biotic stimulus | regulation of cyclin-dependent protein serine/threonine kinase activity | nitrogen compound metabolic process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | negative regulation of cytokine production | defense response to virus | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | regulation of cellular protein metabolic process | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | regulation of protein phosphorylation | protein polyubiquitination | protein metabolic process | protein ubiquitination | regulation of kinase activity | metabolic process | ubiquitin-protein transferase activity | immune response | organic substance metabolic process | protein modification by small protein conjugation or removal | regulation of phosphate metabolic process | cellular protein metabolic process | regulation of cytokine production | ISG15-protein conjugation | response to biotic stimulus | cellular protein modification process | innate immune response | immune system process | cellular metabolic process | response to other organism | macromolecule metabolic process | regulation of phosphorus metabolic process

GO Cellular Component

cell | cytoplasm | perinuclear region of cytoplasm | cytosol | intracellular