QuickView for HIBADH (gene)
- Gene Symbol:
- HIBADH
Homo sapiens - Full name:
- 3-hydroxyisobutyrate dehydrogenase
- Synonyms:
- NS5ATP1, 3-hydroxyisobutyrate dehydrogenase, mitochondrial, 3'-hydroxyisobutyrate dehydrogenase
- Genomic Location:
- Chr 7: 27531586-27669127
- Description:
-
This gene encodes a mitochondrial 3-hydroxyisobutyrate dehydrogenase enzyme. The encoded protein plays a critical role in the catabolism of L-valine by catalyzing the oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
7p15.2
GO Molecular Function
oxidoreductase activity, acting on CH-OH group of donors | NADP binding | cofactor binding | nucleotide binding | coenzyme binding | catalytic activity | 3-hydroxyisobutyrate dehydrogenase activity | organic cyclic compound binding | NAD binding | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | heterocyclic compound binding | oxidoreductase activity | small molecule binding
GO Biological Process
oxidoreductase activity, acting on CH-OH group of donors | branched-chain amino acid metabolic process | cellular amino acid catabolic process | cellular process | organic substance catabolic process | cellular amino acid metabolic process | catabolic process | carboxylic acid catabolic process | valine metabolic process | nitrogen compound metabolic process | 3-hydroxyisobutyrate dehydrogenase activity | small molecule metabolic process | valine catabolic process | carboxylic acid metabolic process | metabolic process | oxidation-reduction process | organic substance metabolic process | organonitrogen compound catabolic process | organic acid metabolic process | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | branched-chain amino acid catabolic process | cellular metabolic process | oxidoreductase activity
GO Cellular Component
mitochondrial matrix | intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | mitochondrion | membrane-bounded organelle | organelle | membrane-enclosed lumen | intracellular
