QuickView for HINT1 (gene)

Gene Symbol:

HINT1 Homo sapiens

Full name:

histidine triad nucleotide binding protein 1

Synonyms:

HINT, NMAN, PKCI-1, PRKCNH1, histidine triad nucleotide-binding protein 1, adenosine 5'-monophosphoramidase, protein kinase C inhibitor 1, protein kinase C-interacting protein 1

Genomic Location:

Chr 5: 130522776-130528935

Description:

This gene encodes a protein that hydrolyzes purine nucleotide phosphoramidates substrates, including AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif. This gene is considered a tumor suppressor gene. In addition, mutations...

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This gene encodes a protein that hydrolyzes purine nucleotide phosphoramidates substrates, including AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif. This gene is considered a tumor suppressor gene. In addition, mutations in this gene can cause autosomal recessive neuromyotonia and axonal neuropathy. There are several related pseudogenes on chromosome 7. Several transcript variants have been observed.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGANNYRGCA_TCF11MAFG_01 ,  TGCGCANK_UNKNOWN ,  AHRARNT_02 ,  LMO2COM_02 ,  GATA4_Q3 ,  GATA1_05 ,  RCGCANGCGY_NRF1_Q6

Cytogenetic Map:

5q23.3

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