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QuickView for HLA-E (gene)


Gene Symbol:
HLA-E Homo sapiens Homo sapiens
Full name:
major histocompatibility complex, class I, E
Synonyms:
HLA-6.2, QA1, HLA class I histocompatibility antigen, alpha chain E, MHC class I antigen E, MHC class Ib antigen
Genomic Location:
Chr 6: 30565250-30569077
Description:
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 4...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Pan troglodytes
External Links:
Entrez Gene
Cytogenetic Map:
chr 6
6p22.1





GO Molecular Function

MHC protein binding | peptide binding | protein-containing complex binding | signaling receptor binding | peptide antigen binding | amide binding | antigen binding | natural killer cell lectin-like receptor binding | T cell receptor binding | protein binding | beta-2-microglobulin binding | MHC class I protein binding

GO Biological Process

positive regulation of immune response | positive regulation of cell killing | regulation of T cell mediated immunity | adaptive immune response | regulation of CD8-positive, alpha-beta T cell proliferation | positive regulation of CD8-positive, alpha-beta T cell proliferation | negative regulation of immune system process | response to cytokine | antigen processing and presentation | regulation of localization | antigen processing and presentation of endogenous peptide antigen via MHC class Ib | cellular response to type I interferon | defense response to other organism | regulation of immune system process | positive regulation of lymphocyte activation | regulation of T cell mediated cytotoxicity | defense response | regulation of leukocyte mediated cytotoxicity | positive regulation of cell adhesion | positive regulation of protein secretion | regulation of immunoglobulin secretion | cellular process | response to type I interferon | positive regulation of immune effector process | positive regulation of adaptive immune response | negative regulation of innate immune response | regulation of immune response | regulation of cellular process | leukocyte activation | interferon-gamma-mediated signaling pathway | positive regulation of interleukin-4 production | T cell activation | cellular response to interferon-gamma | positive regulation of natural killer cell mediated immunity | positive regulation of tumor necrosis factor production | regulation of peptide secretion | response to stimulus | positive regulation of innate immune response | positive regulation of immune system process | positive regulation of immunoglobulin production | response to stress | positive regulation of lymphocyte proliferation | regulation of cell proliferation | positive regulation of cell-cell adhesion | positive regulation of cell activation | positive regulation of T cell activation | regulation of protein transport | regulation of peptide transport | regulation of cell adhesion | positive regulation of peptide secretion | positive regulation of mononuclear cell proliferation | response to external biotic stimulus | regulation of interleukin-4 production | antibacterial humoral response | antigen processing and presentation of endogenous antigen | regulation of T cell activation | negative regulation of natural killer cell mediated cytotoxicity | antigen processing and presentation of exogenous peptide antigen via MHC class I | positive regulation of secretion | positive regulation of alpha-beta T cell proliferation | regulation of lymphocyte activation | cytokine-mediated signaling pathway | positive regulation of interleukin-13 production | protection from natural killer cell mediated cytotoxicity | cellular response to cytokine stimulus | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent | positive regulation of T cell proliferation | negative regulation of immune response | positive regulation of CD8-positive, alpha-beta T cell activation | regulation of tumor necrosis factor production | response to bacterium | positive regulation of TRAIL production | cell communication | humoral immune response | defense response to bacterium | positive regulation of cell proliferation | positive regulation of establishment of protein localization | positive regulation of transport | lymphocyte activation | antimicrobial humoral response | antigen processing and presentation of exogenous antigen | regulation of establishment of protein localization | response to organic substance | regulation of innate immune response | antigen processing and presentation of peptide antigen via MHC class I | cell surface receptor signaling pathway | regulation of adaptive immune response | positive regulation of leukocyte activation | regulation of secretion | immune response | positive regulation of T cell mediated cytotoxicity | regulation of cell activation | regulation of protein secretion | alpha-beta T cell activation | CD8-positive, alpha-beta T cell activation | response to interferon-gamma | positive regulation of cytokine production | cell activation | positive regulation of T cell mediated immunity | regulation of natural killer cell mediated cytotoxicity | positive regulation of protein transport | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | type I interferon signaling pathway | defense response to Gram-positive bacterium | signaling | regulation of immunoglobulin production | regulation of T cell proliferation | regulation of cytokine production | response to biotic stimulus | positive regulation of immunoglobulin secretion | positive regulation of alpha-beta T cell activation | regulation of transport | regulation of cell-cell adhesion | positive regulation of leukocyte mediated cytotoxicity | innate immune response | antigen processing and presentation of peptide antigen | immune system process | regulation of natural killer cell mediated immunity | cellular response to organic substance | regulation of protein localization | positive regulation of leukocyte cell-cell adhesion | response to other organism | signal transduction

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | early endosome membrane | ER to Golgi transport vesicle membrane | endocytic vesicle membrane | organelle membrane | cytoplasmic vesicle | Golgi-associated vesicle membrane | cell | integral component of endoplasmic reticulum membrane | plasma membrane protein complex | COPII-coated ER to Golgi transport vesicle | intrinsic component of membrane | transport vesicle membrane | MHC class I protein complex | cytoplasm | intracellular organelle | intrinsic component of endoplasmic reticulum membrane | endoplasmic reticulum | endosome membrane | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | recycling endosome | integral component of lumenal side of endoplasmic reticulum membrane | phagocytic vesicle membrane | endomembrane system | endoplasmic reticulum membrane | plasma membrane | Golgi-associated vesicle | vesicle | transport vesicle | extracellular exosome | Golgi membrane | endosome | extracellular region | coated vesicle membrane | membrane-bounded organelle | extracellular vesicle | organelle | recycling endosome membrane | vesicle membrane | extracellular space | cell periphery | early endosome | intracellular vesicle | cell surface | endocytic vesicle | intracellular | MHC class Ib protein complex | membrane | cytoplasmic vesicle membrane | phagocytic vesicle | coated vesicle