QuickView for HMT (gene)

Gene Symbol:

HNMT Homo sapiens

Full name:

histamine N-methyltransferase

Synonyms:

HMT, HNMT-S1, HNMT-S2, MRT51, histamine N-methyltransferase

Genomic Location:

Chr 2: 138438278-138490404

Description:

In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is c...

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In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTANTCA_UNKNOWN ,  YATTNATC_UNKNOWN ,  GR_Q6 ,  ATTCTTT_MIR186 ,  GATA1_02

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-186

Cytogenetic Map:

2q22.1

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