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QuickView for HNF1-alpha (gene)


Gene Symbol:
Hnf1a Mus musculus Mus musculus
Full name:
HNF1 homeobox A
Synonyms:
AI323641, HNF1, HNF1-alpha, HNF1[a], Hnf-1, Hnf1alpha, LFB1, Tcf-1, Tcf1, hepatocyte nuclear factor 1-alpha, HNF-1-alpha, HNF-1A, hepatocyte nuclear factor 1, liver-specific transcription factor LF-B1, transcription factor 1
Genomic Location:
Chr 5: 115398370-115421047
Description:
This gene encodes a hepatic transcription factor. The encoded protein is not a member of the T-cell factor family, and is distinct from T-cell specific transcription factor 7 which has also been referred to by the symbol Tcf1.
Orthologs:
Homo sapiens Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Canis lupus familiaris Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
CMYB_01 AACTTT_UNKNOWN MZF1_02 CDPCR3_01 HNF1_01 HNF4_01 OCT1_03 LYF1_01 COUP_01 SRY_02


Transcripts Names
NM_009327
XM_011248192
Protein Names
P22361
E9QP86
Q66JY7



GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | identical protein binding | protein heterodimerization activity | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | protein homodimerization activity | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transcription cofactor binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | limb development | SMAD protein signal transduction | positive regulation of macromolecule biosynthetic process | positive regulation of cellular component organization | developmental process involved in reproduction | regulation of localization | lipid transport | hormone secretion | peptidyl-amino acid modification | establishment of localization | paraxial mesoderm morphogenesis | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | embryonic appendage morphogenesis | histone modification | cell differentiation | bile acid biosynthetic process | glucose homeostasis | bone remodeling | regulation of peptide hormone secretion | mesenchyme development | tissue homeostasis | sterol metabolic process | positive regulation of cellular biosynthetic process | regulation of transcription initiation from RNA polymerase II promoter | cellular process | secretion | peptide hormone secretion | lymphocyte differentiation | monocarboxylic acid transport | localization | chromatin organization | limb morphogenesis | mesoderm morphogenesis | protein transport | tissue remodeling | reproductive system development | mesoderm development | anion transport | immune system development | negative regulation of nucleic acid-templated transcription | macromolecule localization | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | tissue development | anatomical structure homeostasis | heme metabolic process | porphyrin-containing compound metabolic process | regulation of cellular process | leukocyte activation | regulation of metabolic process | regulation of protein complex assembly | hepaticobiliary system development | organic cyclic compound metabolic process | bone resorption | RNA biosynthetic process | cellular aromatic compound metabolic process | steroid biosynthetic process | endocrine pancreas development | cellular component organization | cellular lipid metabolic process | regulation of peptide secretion | response to stimulus | monocarboxylic acid metabolic process | embryonic limb morphogenesis | paraxial mesoderm development | regulation of insulin secretion | natural killer cell differentiation | mesoderm formation | response to stress | monosaccharide transmembrane transport | cellular nitrogen compound biosynthetic process | alcohol metabolic process | multicellular organismal homeostasis | response to glucose | tetrapyrrole biosynthetic process | reproduction | secretion by cell | organic hydroxy compound transport | peptidyl-lysine acetylation | cellular nitrogen compound metabolic process | regulation of protein transport | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cofactor metabolic process | hemopoiesis | protein modification process | regulation of peptide transport | cellular biosynthetic process | embryo development | macromolecule modification | cell-cell signaling | insulin secretion | regulation of nucleic acid-templated transcription | leukocyte differentiation | organic hydroxy compound metabolic process | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | renal glucose absorption | multicellular organism development | protein acetylation | lipid metabolic process | regulation of hormone levels | regulation of hormone secretion | regulation of gene expression | fatty acid transport | pancreas development | organic substance transport | positive regulation of cellular metabolic process | animal organ morphogenesis | cofactor biosynthetic process | liver development | pigment biosynthetic process | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | small molecule metabolic process | renal absorption | peptide transport | hexose transmembrane transport | positive regulation of protein complex assembly | regulation of transcription by RNA polymerase II | response to oxidative stress | organic acid transport | heme biosynthetic process | fatty acid biosynthetic process | histone acetylation | internal peptidyl-lysine acetylation | biosynthetic process | sterol transport | aromatic compound biosynthetic process | mesenchyme morphogenesis | organic anion transport | lipid biosynthetic process | cholesterol transport | endocrine system development | chordate embryonic development | peptide secretion | cell communication | regulation of cellular metabolic process | chromatin remodeling | transmembrane receptor protein serine/threonine kinase signaling pathway | homeostatic process | response to monosaccharide | reverse cholesterol transport | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | carbohydrate transport | embryonic morphogenesis | carboxylic acid metabolic process | lymphocyte activation | carbohydrate transmembrane transport | bile acid metabolic process | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | DNA-binding transcription factor activity | regulation of establishment of protein localization | response to organic substance | gland development | tissue morphogenesis | anatomical structure development | cell surface receptor signaling pathway | metabolic process | lipid localization | positive regulation of DNA-templated transcription, initiation | regulation of RNA biosynthetic process | cholesterol metabolic process | negative regulation of transcription, DNA-templated | glucose import | amide transport | peptidyl-lysine modification | bile acid and bile salt transport | chemical homeostasis | regulation of secretion | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | hormone transport | nucleobase-containing compound metabolic process | positive regulation of cellular component biogenesis | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | pigment metabolic process | animal organ development | gene expression | regulation of protein secretion | regulation of Wnt signaling pathway | renal system process | fatty acid metabolic process | establishment of protein localization | transcription, DNA-templated | blastocyst development | cell activation | glucose transmembrane transport | anatomical structure formation involved in morphogenesis | steroid metabolic process | regulation of cell communication | paraxial mesoderm formation | transmembrane transport | natural killer cell activation | signaling | covalent chromatin modification | regulation of transcription, DNA-templated | internal protein amino acid acetylation | protein localization | organic acid metabolic process | cellular protein metabolic process | carboxylic acid transport | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | regulation of DNA-templated transcription, initiation | reproductive structure development | developmental process | organelle organization | cellular protein modification process | negative regulation of transcription by RNA polymerase II | regulation of transport | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | signal release | formation of primary germ layer | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | in utero embryonic development | positive regulation of metabolic process | chromosome organization | ion transport | gastrulation | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | placenta development | regulation of protein localization | protein secretion | response to carbohydrate | carbohydrate homeostasis | porphyrin-containing compound biosynthetic process | regulation of cellular component organization | positive regulation of transcription initiation from RNA polymerase II promoter | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

non-motile cilium | intracellular membrane-bounded organelle | neuron projection | cell | transcription factor complex | cytoplasm | intracellular organelle | protein-containing complex | cell projection | pronucleus | cilium | photoreceptor outer segment | 9+0 non-motile cilium | photoreceptor cell cilium | membrane-bounded organelle | nucleus | organelle | intracellular