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QuickView for HPGD (gene)

Gene Symbol:
HPGD Homo sapiens Homo sapiens
Full name:
15-hydroxyprostaglandin dehydrogenase
15-PGDH, PGDH, PGDH1, PHOAR1, SDR36C1, 15-hydroxyprostaglandin dehydrogenase [NAD(+)], 15-hydroxyprostaglandin dehydrogenase (NAD(+)), NAD+-dependent 15-hydroxyprostaglandin dehydrogenase, hydroxyprostaglandin dehydrogenase 15-(NAD), prostaglandin dehydrogenase 1, short chain dehydrogenase/reductase family 36C member 1
Genomic Location:
Chr 4: 175647955-175680186
This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropath...
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 4

GO Molecular Function

oxidoreductase activity, acting on CH-OH group of donors | cofactor binding | prostaglandin receptor activity | transmembrane signaling receptor activity | nucleotide binding | G-protein coupled receptor activity | coenzyme binding | NAD+ binding | catalytic activity | anion binding | signaling receptor activity | identical protein binding | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity | ion binding | organic cyclic compound binding | protein binding | protein homodimerization activity | prostaglandin E receptor activity | NAD binding | protein dimerization activity | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | heterocyclic compound binding | oxidoreductase activity | small molecule binding

GO Biological Process

positive regulation of smooth muscle cell proliferation | oxidoreductase activity, acting on CH-OH group of donors | response to lipopolysaccharide | positive regulation of apoptotic process | regulation of programmed cell death | response to hormone | negative regulation of cellular process | response to drug | response to antibiotic | blood vessel morphogenesis | positive regulation of vascular smooth muscle cell proliferation | prostaglandin receptor activity | cellular process | unsaturated fatty acid biosynthetic process | response to estradiol | female pregnancy | multicellular organismal reproductive process | regulation of cell cycle | response to growth factor | gamete generation | regulation of cellular process | parturition | regulation of apoptotic process | icosanoid biosynthetic process | cellular lipid metabolic process | response to transforming growth factor beta | urogenital system development | G-protein coupled receptor activity | response to stimulus | ovulation | vasculature development | female gamete generation | monocarboxylic acid metabolic process | regulation of cell proliferation | tube morphogenesis | reproduction | response to alcohol | cardiovascular system development | response to molecule of bacterial origin | ductus arteriosus closure | G-protein coupled receptor signaling pathway | cellular biosynthetic process | kidney development | blood vessel development | response to ethanol | response to external biotic stimulus | system development | reproductive process | multicellular organism development | lipid metabolic process | artery development | response to lipid | enzyme linked receptor protein signaling pathway | small molecule metabolic process | fatty acid biosynthetic process | biosynthetic process | long-chain fatty acid biosynthetic process | lipid biosynthetic process | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity | response to toxic substance | lipoxygenase pathway | response to bacterium | cell communication | transmembrane receptor protein serine/threonine kinase signaling pathway | positive regulation of cell proliferation | renal system development | long-chain fatty acid metabolic process | carboxylic acid metabolic process | cellular response to transforming growth factor beta stimulus | multicellular organism reproduction | response to organic substance | artery morphogenesis | prostaglandin E receptor activity | anatomical structure development | cell surface receptor signaling pathway | metabolic process | oxidation-reduction process | prostaglandin metabolic process | positive regulation of cell death | lipoxin biosynthetic process | organic substance metabolic process | animal organ development | positive regulation of programmed cell death | thrombin-activated receptor signaling pathway | fatty acid metabolic process | transforming growth factor beta receptor signaling pathway | negative regulation of cell cycle | icosanoid metabolic process | signaling | response to organic cyclic compound | organic acid metabolic process | anatomical structure morphogenesis | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | response to biotic stimulus | developmental process | tube development | cellular metabolic process | cellular response to organic substance | regulation of cell death | regulation of smooth muscle cell proliferation | oxidoreductase activity | circulatory system development | sexual reproduction | response to other organism | signal transduction | cellular response to growth factor stimulus | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | plasma membrane | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | cell periphery | membrane-enclosed lumen | basolateral plasma membrane | cytosol | intracellular | membrane