QuickView for HPGD (gene)

Gene Symbol:

HPGD Homo sapiens

Full name:

15-hydroxyprostaglandin dehydrogenase

Synonyms:

15-PGDH, PGDH, PGDH1, PHOAR1, SDR36C1, 15-hydroxyprostaglandin dehydrogenase [NAD(+)], 15-hydroxyprostaglandin dehydrogenase (NAD(+)), NAD+-dependent 15-hydroxyprostaglandin dehydrogenase, hydroxyprostaglandin dehydrogenase 15-(NAD), prostaglandin dehydrogenase 1, short chain dehydrogenase/reductase family 36C member 1

Genomic Location:

Chr 4: 175647955-175680186

Description:

This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropath...

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This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HNF4ALPHA_Q6 ,  YTATTTTNR_MEF2_02 ,  TACTTGA_MIR26A_MIR26B ,  MEF2_02 ,  CAGGTG_E12_Q6 ,  GGGCGGR_SP1_Q6 ,  TGCCAAR_NF1_Q6 ,  USF_Q6_01 ,  TAATTA_CHX10_01 ,  MEF2_03

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-378

Cytogenetic Map:

4q34.1

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