QuickView for HPGDS (gene)
- Gene Symbol:
- HPGDS
Homo sapiens - Full name:
- hematopoietic prostaglandin D synthase
- Synonyms:
- GSTS, GSTS1, GSTS1-1, PGD2, PGDS, hematopoietic prostaglandin D synthase, GST class-sigma, glutathione S-transferase sigma, glutathione-dependent PGD synthase, glutathione-dependent PGD synthetase, glutathione-requiring prostaglandin D synthase, hematopoietic prostaglandin D2 synthase, prostaglandin-H2 D-isomerase
- Genomic Location:
- Chr 4: 95438730-95483050
- Description:
-
Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Bos taurus , Gallus gallus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
4q22.3
GO Molecular Function
glutathione transferase activity | cation binding | magnesium ion binding | isomerase activity | transferase activity, transferring alkyl or aryl (other than methyl) groups | catalytic activity | intramolecular oxidoreductase activity | identical protein binding | ion binding | protein binding | protein homodimerization activity | protein dimerization activity | transferase activity | calcium ion binding | metal ion binding | prostaglandin-D synthase activity
GO Biological Process
sulfur compound metabolic process | negative regulation of cellular process | glutathione derivative biosynthetic process | cellular process | unsaturated fatty acid biosynthetic process | regulation of cellular process | icosanoid biosynthetic process | cellular lipid metabolic process | response to stimulus | monocarboxylic acid metabolic process | regulation of germ cell proliferation | regulation of cell proliferation | cyclooxygenase pathway | cellular biosynthetic process | nitrogen compound metabolic process | lipid metabolic process | small molecule metabolic process | fatty acid biosynthetic process | biosynthetic process | locomotory behavior | negative regulation of male germ cell proliferation | lipid biosynthetic process | cell communication | long-chain fatty acid metabolic process | carboxylic acid metabolic process | metabolic process | prostaglandin metabolic process | behavior | organic substance metabolic process | fatty acid metabolic process | icosanoid metabolic process | signaling | organic acid metabolic process | negative regulation of cell proliferation | prostaglandin biosynthetic process | regulation of male germ cell proliferation | cellular metabolic process | arachidonic acid metabolic process | signal transduction
GO Cellular Component
cell | cytoplasm | cytosol | intracellular
