QuickView for HR (gene)

Gene Symbol:

HR Homo sapiens

Full name:

HR, lysine demethylase and nuclear receptor corepressor

Synonyms:

ALUNC, AU, HSA277165, HYPT4, MUHH, MUHH1, lysine-specific demethylase hairless, hair growth associated, hairless homolog, protein hairless

Genomic Location:

Chr 8: 22027877-22043975

Description:

This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modula...

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This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

FOXO1_02 ,  E12_Q6 ,  RTAAACA_FREAC2_01 ,  CMYB_01 ,  MAZR_01 ,  GATA1_01 ,  MZF1_01 ,  FOXO4_01 ,  HFH1_01 ,  AREB6_04 ,  AP2GAMMA_01 ,  PAX8_01 ,  AP2ALPHA_01 ,  E2F1_Q4 ,  GGGAGGRR_MAZ_Q6 ,  HNF4_01 ,  LEF1_Q6 ,  CACCCBINDINGFACTOR_Q6 ,  FOXO3_01 ,  GGATTA_PITX2_Q2 ,  E2F1_Q6_01 ,  CAGGTG_E12_Q6 ,  TGCGCANK_UNKNOWN ,  ZID_01 ,  MYOD_Q6 ,  GGGCGGR_SP1_Q6 ,  CCCNNGGGAR_OLF1_01 ,  E2F1_Q3_01 ,  TGCCAAR_NF1_Q6 ,  SPZ1_01 ,  TGTTTGY_HNF3_Q6 ,  HFH8_01 ,  PAX8_B ,  FREAC2_01 ,  MTF1_Q4 ,  TTGTTT_FOXO4_01 ,  RGAGGAARY_PU1_Q6 ,  ZIC2_01 ,  TGACAGNY_MEIS1_01 ,  CTTTGT_LEF1_Q2 ,  EGR1_01 ,  YRCCAKNNGNCGC_UNKNOWN ,  CACBINDINGPROTEIN_Q6 ,  ZF5_B ,  MZF1_02 ,  CRX_Q4 ,  PPARA_02 ,  FREAC4_01 ,  HNF4_01_B ,  FOXO4_02 ,  TATTATA_MIR374 ,  CP2_01 ,  GGGTGGRR_PAX4_03

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Cytogenetic Map:

8p21.3

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