QuickView for HSD11B1 (gene)

Gene Symbol:

HSD11B1 Homo sapiens

Full name:

hydroxysteroid 11-beta dehydrogenase 1

Synonyms:

11-DH, 11-beta-HSD1, CORTRD2, HDL, HSD11, HSD11B, HSD11L, SDR26C1, corticosteroid 11-beta-dehydrogenase isozyme 1, short chain dehydrogenase/reductase family 26C member 1

Genomic Location:

Chr 1: 207926173-207974918

Description:

The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene...

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The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  GATTGGY_NFY_Q6_01 ,  AACWWCAANK_UNKNOWN ,  RTAAACA_FREAC2_01 ,  ALX4_01 ,  STAT4_01 ,  MAZR_01 ,  FOXJ2_02 ,  RYTTCCTG_ETS2_B ,  MAZ_Q6 ,  P53_DECAMER_Q2 ,  YTATTTTNR_MEF2_02 ,  CATTGTYY_SOX9_B1 ,  STAT6_02 ,  HFH1_01 ,  LYF1_01 ,  CTTTGA_LEF1_Q2 ,  HEB_Q6 ,  WTGAAAT_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  TGAYRTCA_ATF3_Q6 ,  TAL1BETAE47_01 ,  LEF1_Q6 ,  LEF1_Q2 ,  CAGGTG_E12_Q6 ,  AP4_Q6 ,  CCAWYNNGAAR_UNKNOWN ,  ATF3_Q6 ,  NKX61_01 ,  GAANYNYGACNY_UNKNOWN ,  MEIS1_01 ,  SOX5_01 ,  GFI1_01 ,  HAND1E47_01 ,  YTAAYNGCT_UNKNOWN ,  ATF1_Q6 ,  CEBP_C ,  TAL1BETAITF2_01 ,  CAGCTG_AP4_Q5 ,  FOXM1_01 ,  SRY_02 ,  AP4_Q5 ,  MZF1_02 ,  ACAWYAAAG_UNKNOWN ,  TGACATY_UNKNOWN ,  CEBPGAMMA_Q6 ,  GGGTGGRR_PAX4_03 ,  CCTNTMAGA_UNKNOWN ,  TCF11MAFG_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-326

Cytogenetic Map:

1q32.2

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