QuickView for HSD17B6 (gene)
- Gene Symbol:
- HSD17B6
Homo sapiens - Full name:
- hydroxysteroid 17-beta dehydrogenase 6
- Synonyms:
- HSE, RODH, SDR9C6, 17-beta-hydroxysteroid dehydrogenase type 6, 17-beta-HSD 6, 17-beta-hydroxysteroid dehydrogenase type 6 variant 1, 17-beta-hydroxysteroid dehydrogenase type 6 variant 2, 17-beta-hydroxysteroid dehydrogenase type 6 variant 3, 3(alpha->beta)-hydroxysteroid epimerase, 3(alpha->beta)-hydroxysteroid epimerasel, 3-alpha->beta-HSE, 3-hydroxysteroid epimerase, NAD+ -dependent 3 alpha-hydroxysteroid dehydrogenase 3-hydroxysteroid epimerase, hydroxysteroid (17-beta) dehydrogenase 6 homolog, oxidative 3-alpha-hydroxysteroid-dehydrogenase, oxidoreductase, retinol dehydrogenase, short chain dehydrogenase/reductase family 9C member 6
- Genomic Location:
- Chr 12: 55443375-55467841
- Description:
-
The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
12q13.3
GO Molecular Function
retinol dehydrogenase activity | oxidoreductase activity, acting on CH-OH group of donors | steroid dehydrogenase activity | estradiol 17-beta-dehydrogenase activity | testosterone dehydrogenase (NAD+) activity | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | catalytic activity | electron transfer activity | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | oxidoreductase activity
GO Biological Process
retinol dehydrogenase activity | oxidoreductase activity, acting on CH-OH group of donors | steroid dehydrogenase activity | estradiol 17-beta-dehydrogenase activity | generation of precursor metabolites and energy | cellular process | organic substance catabolic process | testosterone dehydrogenase (NAD+) activity | catabolic process | organic cyclic compound metabolic process | steroid biosynthetic process | electron transport chain | androgen biosynthetic process | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | androgen metabolic process | cellular biosynthetic process | hormone biosynthetic process | steroid catabolic process | lipid metabolic process | regulation of hormone levels | electron transfer activity | biosynthetic process | lipid biosynthetic process | androgen catabolic process | hormone catabolic process | metabolic process | oxidation-reduction process | lipid catabolic process | organic substance metabolic process | steroid metabolic process | hormone metabolic process | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | cellular metabolic process | oxidoreductase activity
GO Cellular Component
intracellular membrane-bounded organelle | early endosome membrane | organelle membrane | cytoplasmic vesicle | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | endosome membrane | endomembrane system | vesicle | endosome | membrane-bounded organelle | organelle | early endosome | intracellular vesicle | intracellular | membrane
