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QuickView for HSD17B8 (gene)


Gene Symbol:
HSD17B8 Homo sapiens Homo sapiens
Full name:
hydroxysteroid 17-beta dehydrogenase 8
Synonyms:
D6S2245E, FABG, FABGL, H2-KE6, HKE6, KE6, RING2, SDR30C1, dJ1033B10.9, estradiol 17-beta-dehydrogenase 8, 17-beta-HSD 8, 17-beta-hydroxysteroid dehydrogenase 8, 3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit, 3-oxoacyl-[acyl-carrier-protein] reductase, KAR alpha subunit, estrogen 17-oxidoreductase, ke-6, protein Ke6, really interesting new gene 2 protein, short chain dehydrogenase/reductase family 30C member 1, testosterone 17-beta-dehydrogenase 8
Genomic Location:
Chr 6: 33280397-33282585
Description:
In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. T...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Bos taurus Canis lupus familiaris Danio rerio Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 6
6p21.32


Transcripts Names
NM_014234



GO Molecular Function

oxidoreductase activity, acting on CH-OH group of donors | steroid dehydrogenase activity | cofactor binding | estradiol 17-beta-dehydrogenase activity | 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity | testosterone dehydrogenase (NAD+) activity | nucleotide binding | coenzyme binding | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | catalytic activity | anion binding | NADH binding | ion binding | organic cyclic compound binding | protein binding | NAD binding | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | heterocyclic compound binding | oxidoreductase activity | small molecule binding | 3-hydroxyacyl-CoA dehydrogenase activity

GO Biological Process

protein heterotetramerization | oxidoreductase activity, acting on CH-OH group of donors | steroid dehydrogenase activity | estradiol 17-beta-dehydrogenase activity | estrogen biosynthetic process | estrogen metabolic process | 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity | cellular process | testosterone dehydrogenase (NAD+) activity | organic cyclic compound metabolic process | steroid biosynthetic process | cellular component organization | cellular lipid metabolic process | monocarboxylic acid metabolic process | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | androgen metabolic process | cellular component assembly | cellular biosynthetic process | hormone biosynthetic process | protein complex oligomerization | lipid metabolic process | regulation of hormone levels | small molecule metabolic process | fatty acid biosynthetic process | biosynthetic process | lipid biosynthetic process | protein tetramerization | carboxylic acid metabolic process | protein-containing complex assembly | metabolic process | oxidation-reduction process | organic substance metabolic process | fatty acid metabolic process | steroid metabolic process | organic acid metabolic process | hormone metabolic process | protein heterooligomerization | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | cellular metabolic process | oxidoreductase activity | 3-hydroxyacyl-CoA dehydrogenase activity

GO Cellular Component

mitochondrial matrix | intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | plasma membrane | mitochondrion | membrane-bounded organelle | organelle | mitochondrial envelope | cell periphery | membrane-enclosed lumen | intracellular | membrane