QuickView for HSF1;jsessionid=91BC1990B7EBE0741E0D812445D99AB6 (gene)
- Gene Symbol:
- HSF1
Homo sapiens - Full name:
- heat shock transcription factor 1
- Synonyms:
- HSTF1, heat shock factor protein 1
- Genomic Location:
- Chr 8: 145486078-145509193
- Description:
-
The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phosphorylation, which promotes binding by heat shock protein 90.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
8q24.3
GO Molecular Function
sequence-specific DNA binding | protein self-association | kinase binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | sequence-specific single stranded DNA binding | protein kinase binding | proximal promoter sequence-specific DNA binding | enzyme binding | intronic transcription regulatory region sequence-specific DNA binding | nucleic acid binding | single-stranded DNA binding | STAT family protein binding | chromatin binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | promoter-specific chromatin binding | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | identical protein binding | protein heterodimerization activity | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | DNA-binding transcription factor activity | chromatin DNA binding | intronic transcription regulatory region DNA binding | protein dimerization activity | translation elongation factor binding | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | Hsp90 protein binding | heat shock protein binding | heterocyclic compound binding | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO Biological Process
RNA metabolic process | response to extracellular stimulus | protein homooligomerization | response to radiation | positive regulation of macromolecule biosynthetic process | regulation of cysteine-type endopeptidase activity | response to nutrient levels | positive regulation of microtubule binding | RNA processing | positive regulation of cellular component organization | response to lipopolysaccharide | developmental process involved in reproduction | intracellular signal transduction | positive regulation of apoptotic process | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | establishment of localization | response to hormone | negative regulation of neuron death | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | positive regulation of developmental process | response to potassium ion | negative regulation of RNA biosynthetic process | response to metal ion | regulation of cardiac muscle cell apoptotic process | regulation of mRNA polyadenylation | male gamete generation | response to hypobaric hypoxia | defense response | cellular response to extracellular stimulus | response to drug | positive regulation of phosphate metabolic process | response to antibiotic | negative regulation of DNA metabolic process | regulation of DNA repair | regulation of mRNA processing | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | localization | response to psychosocial stress | reproductive system development | response to estradiol | female pregnancy | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | cellular response to potassium ion | macromolecule localization | negative regulation of apoptotic process | response to hypoxia | regulation of proteolysis | regulation of cell cycle | positive regulation of catalytic activity | regulation of tyrosine phosphorylation of STAT protein | regulation of multicellular organism growth | positive regulation of nitrogen compound metabolic process | response to inorganic substance | negative regulation of cellular metabolic process | response to peptide hormone | regulation of binding | gamete generation | cellular response to diamide | cellular response to L-glutamine | response to hydrogen peroxide | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | negative regulation of DNA repair | cellular response to molecule of bacterial origin | negative regulation of tumor necrosis factor production | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular response to unfolded protein | cellular response to organonitrogen compound | response to topologically incorrect protein | cellular aromatic compound metabolic process | cellular component organization | MAPK cascade | cellular response to topologically incorrect protein | cellular response to metal ion | positive regulation of protein binding | cellular response to salt | response to stimulus | female gamete generation | positive regulation of cold-induced thermogenesis | regulation of cellular response to heat | regulation of peptidyl-tyrosine phosphorylation | positive regulation of protein metabolic process | positive regulation of peptidase activity | signal transduction by protein phosphorylation | cellular response to xenobiotic stimulus | response to stress | positive regulation of JAK-STAT cascade | negative regulation of tumor necrosis factor superfamily cytokine production | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | regulation of double-strand break repair | response to peptide | positive regulation of cysteine-type endopeptidase activity | protein homotrimerization | reproduction | cellular response to inorganic substance | response to temperature stimulus | cellular response to cadmium ion | positive regulation of proteolysis | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | cellular response to toxic substance | positive regulation of apoptotic DNA fragmentation | positive regulation of transcription from RNA polymerase II promoter in response to heat stress | cellular response to organic cyclic compound | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | positive regulation of mRNA processing | protein modification process | mRNA metabolic process | cellular biosynthetic process | positive regulation of multicellular organism growth | embryo development | macromolecule modification | response to herbicide | embryonic placenta development | DNA repair | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | response to nitrogen compound | positive regulation of DNA catabolic process | cellular response to hormone stimulus | response to external biotic stimulus | system development | cellular response to nutrient levels | response to oxygen levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | cellular response to antibiotic | multicellular organism development | response to activity | cellular response to peptide hormone stimulus | regulation of peptidase activity | phosphorus metabolic process | response to amino acid | negative regulation of striated muscle cell apoptotic process | cellular response to DNA damage stimulus | protein complex oligomerization | regulation of catalytic activity | cellular response to oxidative stress | regulation of phosphorylation | response to nitroglycerin | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of gene expression | organic substance transport | response to ketone | cellular response to stress | response to lipid | cellular response to peptide | cell cycle | cellular response to heat | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular response to radiation | regulation of mRNA 3'-end processing | regulation of nitrogen compound metabolic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | cellular response to nitroglycerin | positive regulation of STAT cascade | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | response to nutrient | cellular response to gamma radiation | response to oxidative stress | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | positive regulation of hydrolase activity | negative regulation of double-strand break repair | negative regulation of cardiac muscle cell apoptotic process | negative regulation of double-strand break repair via nonhomologous end joining | biosynthetic process | response to cadmium ion | positive regulation of mRNA polyadenylation | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | positive regulation of transcription from RNA polymerase II promoter in response to stress | mRNA transport | phosphorylation | positive regulation of endopeptidase activity | cellular protein-containing complex assembly | response to toxic substance | establishment of RNA localization | response to xenobiotic stimulus | cellular response to amino acid stimulus | protein phosphorylation | regulation of tumor necrosis factor production | response to gamma radiation | regulation of apoptotic DNA fragmentation | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | phosphate-containing compound metabolic process | cellular response to angiotensin | cellular response to drug | regulation of microtubule binding | response to bacterium | regulation of muscle cell apoptotic process | chordate embryonic development | cell communication | regulation of cellular metabolic process | response to testosterone | protein trimerization | positive regulation of tyrosine phosphorylation of STAT protein | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of cell proliferation | mRNA transcription | regulation of protein phosphorylation | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | regulation of double-strand break repair via nonhomologous end joining | response to insecticide | regulation of mitotic cell cycle | positive regulation of molecular function | response to angiotensin | multicellular organism reproduction | positive regulation of execution phase of apoptosis | protein-containing complex assembly | protein metabolic process | cellular response to nutrient | DNA-binding transcription factor activity | positive regulation of protein modification process | regulation of growth | response to organic substance | regulation of JAK-STAT cascade | DNA metabolic process | response to antineoplastic agent | regulation of intracellular signal transduction | anatomical structure development | regulation of protein heterodimerization activity | nucleobase-containing compound transport | nuclear division | metabolic process | regulation of DNA-templated transcription in response to stress | cellular response to arsenic-containing substance | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | embryonic organ development | cellular response to hydrogen peroxide | negative regulation of muscle cell apoptotic process | positive regulation of cell death | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | regulation of response to DNA damage stimulus | nucleobase-containing compound metabolic process | cellular response to reactive oxygen species | positive regulation of cellular component biogenesis | organic substance metabolic process | response to copper ion | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | response to reactive oxygen species | gene expression | positive regulation of programmed cell death | response to heat | cellular response to ionizing radiation | positive regulation of mRNA 3'-end processing | regulation of phosphate metabolic process | negative regulation of inclusion body assembly | positive regulation of binding | transcription, DNA-templated | RNA transport | cellular response to estradiol stimulus | meiotic cell cycle | regulation of cell communication | response to arsenic-containing substance | positive regulation of developmental growth | signaling | positive regulation of growth | regulation of transcription, DNA-templated | regulation of protein binding | response to organic cyclic compound | regulation of developmental growth | positive regulation of phosphorylation | cellular protein metabolic process | regulation of transcription from RNA polymerase II promoter in response to stress | response to unfolded protein | regulation of cytokine production | regulation of endopeptidase activity | cellular macromolecule biosynthetic process | response to biotic stimulus | reproductive structure development | regulation of developmental process | positive regulation of DNA metabolic process | developmental process | organelle organization | spermatogenesis | cellular protein modification process | regulation of inclusion body assembly | response to salt | negative regulation of transcription by RNA polymerase II | positive regulation of inclusion body assembly | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | embryonic process involved in female pregnancy | cellular response to sodium arsenite | in utero embryonic development | positive regulation of metabolic process | regulation of execution phase of apoptosis | cellular metabolic process | mRNA processing | placenta development | cellular response to organic substance | regulation of cell death | cellular response to copper ion | negative regulation of cell death | RNA localization | sexual reproduction | regulation of cellular component organization | response to ionizing radiation | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | female meiotic nuclear division | positive regulation of gene expression | response to sodium arsenite | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
chromosome | intracellular membrane-bounded organelle | nuclear stress granule | microtubule organizing center | chromosome, centromeric region | condensed chromosome, centromeric region | cell | nuclear lumen | ribonucleoprotein granule | kinetochore | cytoplasm | spindle | intracellular organelle | nuclear body | centrosome | euchromatin | protein-containing complex | pronucleus | PML body | nucleoplasm | chromatin | ribonucleoprotein complex | condensed chromosome kinetochore | perinuclear region of cytoplasm | microtubule cytoskeleton | spindle pole | membrane-bounded organelle | heterochromatin | nucleus | organelle | membrane-enclosed lumen | cytosol | cytoskeleton | mitotic spindle pole | intracellular | mitotic spindle | condensed chromosome
