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QuickView for HSP90AA1 (gene)


Gene Symbol:
HSP90AA1 Homo sapiens Homo sapiens
Full name:
heat shock protein 90 alpha family class A member 1
Synonyms:
EL52, HEL-S-65p, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp103, Hsp89, Hsp90, LAP-2, LAP2, heat shock protein HSP 90-alpha, HSP 86, LPS-associated protein 2, epididymis luminal secretory protein 52, epididymis secretory sperm binding protein Li 65p, heat shock 86 kDa, heat shock 90kD protein 1, alpha, heat shock 90kD protein 1, alpha-like 4, heat shock 90kD protein, alpha-like 4, heat shock 90kDa protein 1, alpha, heat shock protein 90kDa alpha (cytosolic), class A member 1, heat shock protein 90kDa alpha family class A member 1, lipopolysaccharide-associated protein 2, renal carcinoma antigen NY-REN-38
Genomic Location:
Chr 14: 101616828-101675839
Description:
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Saccharomyces cerevisiae Macaca mulatta Bos taurus Gallus gallus Canis lupus familiaris Danio rerio Pan troglodytes
External Links:
Entrez Gene
Cytogenetic Map:
chr 14
14q32.31





GO Molecular Function

kinase binding | GTPase binding | protein kinase binding | enzyme binding | nucleic acid binding | protein-containing complex binding | ribonucleotide binding | DNA polymerase binding | disordered domain specific binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | unfolded protein binding | ATPase activity | pyrophosphatase activity | molecular function regulator | catalytic activity | protein domain specific binding | ATP binding | ubiquitin-like protein ligase binding | cytoskeletal protein binding | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | tau protein binding | ATPase activity, coupled | purine nucleotide binding | identical protein binding | TPR domain binding | scaffold protein binding | MHC class II protein complex binding | ion binding | organic cyclic compound binding | protein tyrosine kinase binding | purine ribonucleoside triphosphate binding | protein tyrosine kinase activity | protein binding | protein homodimerization activity | ubiquitin protein ligase binding | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | nitric-oxide synthase regulator activity | hydrolase activity, acting on acid anhydrides | protein kinase activity | transferase activity | purine ribonucleotide binding | enzyme regulator activity | adenyl ribonucleotide binding | drug binding | kinase activity | histone deacetylase binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding | RNA binding

GO Biological Process

positive regulation of immune response | cell morphogenesis | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | telomere maintenance | exocytosis | response to cytokine | positive regulation of cellular component organization | neuron projection morphogenesis | immune response-regulating signaling pathway | neutrophil activation | regulation of cellular localization | protein stabilization | protein localization to mitochondrion | regulation of localization | peptidyl-amino acid modification | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | regulation of nitric oxide biosynthetic process | cell differentiation | immune response-activating cell surface receptor signaling pathway | nervous system development | positive regulation of protein catabolic process | cell part morphogenesis | positive regulation of tau-protein kinase activity | neurogenesis | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | generation of neurons | membrane organization | response to antibiotic | intracellular transport | neuron projection extension | positive regulation of cellular biosynthetic process | cellular process | telomere maintenance via telomerase | secretion | Fc-gamma receptor signaling pathway involved in phagocytosis | organic substance catabolic process | leukocyte degranulation | central nervous system neuron axonogenesis | localization | cell projection morphogenesis | protein transport | developmental growth | positive regulation of peptidyl-serine phosphorylation | neuron development | positive regulation of reactive oxygen species metabolic process | central nervous system neuron differentiation | establishment of protein localization to mitochondrion | positive regulation of telomerase activity | positive regulation of protein kinase activity | macromolecule localization | membrane docking | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | establishment of localization in cell | chaperone-mediated autophagy | anatomical structure homeostasis | regulation of protein kinase B signaling | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of metabolic process | catabolic process | regulation of protein complex assembly | organelle localization | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | response to topologically incorrect protein | cellular aromatic compound metabolic process | regulation of G2/M transition of mitotic cell cycle | establishment of cell polarity | cellular component organization | positive regulation of cellular protein catabolic process | outer mitochondrial membrane organization | response to stimulus | cell morphogenesis involved in neuron differentiation | regulation of cellular protein localization | neutrophil degranulation | regulation of mitotic cell cycle phase transition | regulation of cellular response to heat | positive regulation of nitric oxide metabolic process | positive regulation of immune system process | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | response to cold | response to stress | intracellular protein transport | leukocyte activation involved in immune response | cellular nitrogen compound biosynthetic process | establishment of protein localization to mitochondrial membrane | regulation of protein ubiquitination | protein unfolding | regulation of cell cycle phase transition | cellular localization | secretion by cell | response to temperature stimulus | cellular nitrogen compound metabolic process | telomere organization | immune response-activating signal transduction | ERBB signaling pathway | cofactor metabolic process | cellular component assembly | protein modification process | cellular biosynthetic process | mitochondrion organization | macromolecule modification | telomere maintenance via telomere lengthening | molecular function regulator | ERBB2 signaling pathway | ciliary basal body-plasma membrane docking | regulation of cellular response to stress | regulation of neurotransmitter levels | central nervous system neuron development | organelle assembly | regulation of cell cycle G2/M phase transition | positive regulation of reactive oxygen species biosynthetic process | system development | nitrogen compound metabolic process | regulation of signal transduction | regulation of protein stability | multicellular organism development | phosphorus metabolic process | regulation of tau-protein kinase activity | leukocyte mediated immunity | positive regulation of protein kinase B signaling | regulation of catalytic activity | regulation of phosphorylation | telomerase holoenzyme complex assembly | regulation of nitric-oxide synthase activity | Fc-gamma receptor signaling pathway | DNA biosynthetic process | protein localization to membrane | axon development | organic substance transport | cell cycle | protein catabolic process | cell projection assembly | RNA-dependent DNA biosynthetic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of telomerase activity | mitochondrial transport | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | peptide transport | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | positive regulation of protein complex assembly | cellular amide metabolic process | vesicle-mediated transport | axonogenesis | protein localization to organelle | cellular response to cytokine stimulus | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | G2/M transition of mitotic cell cycle | phosphorylation | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | regulated exocytosis | cellular protein-containing complex assembly | mitotic cell cycle phase transition | protein phosphorylation | cell morphogenesis involved in differentiation | establishment or maintenance of cell polarity | phosphate-containing compound metabolic process | autophagy | protein import | mitochondrial membrane organization | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of DNA biosynthetic process | cell activation involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | neutrophil activation involved in immune response | cell cycle G2/M phase transition | homeostatic process | regulation of protein phosphorylation | peptide metabolic process | regulation of mitotic cell cycle | protein tyrosine kinase activity | positive regulation of molecular function | establishment of protein localization to membrane | neuron differentiation | protein-containing complex assembly | activation of immune response | protein metabolic process | positive regulation of protein modification process | response to organic substance | regulation of kinase activity | DNA metabolic process | import into cell | chaperone-mediated protein complex assembly | axon extension | regulation of intracellular signal transduction | establishment of protein localization to organelle | anatomical structure development | developmental growth involved in morphogenesis | mitotic cell cycle | cell surface receptor signaling pathway | cell projection organization | metabolic process | regulation of protein catabolic process | cellular protein localization | amide transport | nitric-oxide synthase regulator activity | endocytosis | immune response | nucleobase-containing compound metabolic process | protein kinase activity | neuron projection development | positive regulation of cellular component biogenesis | organic substance metabolic process | protein folding | cilium assembly | ribonucleoprotein complex assembly | positive regulation of kinase activity | response to heat | regulation of phosphate metabolic process | establishment of protein localization | cell activation | regulation of reactive oxygen species biosynthetic process | regulation of peptidyl-serine phosphorylation | cilium organization | organonitrogen compound catabolic process | regulation of cell communication | signaling | regulation of oxidoreductase activity | cell development | protein localization | positive regulation of phosphorylation | cellular protein metabolic process | enzyme regulator activity | response to unfolded protein | anatomical structure morphogenesis | cellular macromolecule localization | cellular macromolecule biosynthetic process | protein targeting to mitochondrion | receptor-mediated endocytosis | positive regulation of DNA metabolic process | kinase activity | developmental process | organelle organization | regulation of DNA biosynthetic process | Fc receptor signaling pathway | cellular protein modification process | vascular endothelial growth factor receptor signaling pathway | Fc receptor mediated stimulatory signaling pathway | regulation of reactive oxygen species metabolic process | developmental cell growth | positive regulation of protein polymerization | neutrophil mediated immunity | cell cycle phase transition | heterocycle metabolic process | protein refolding | positive regulation of nitric oxide biosynthetic process | central nervous system development | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | chromosome organization | protein targeting | ribonucleoprotein complex biogenesis | immune system process | cellular metabolic process | cellular response to organic substance | regulation of protein localization | phagocytosis | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process | protein import into mitochondrial outer membrane | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | dendrite | intracellular membrane-bounded organelle | neuron projection | ruffle | somatodendritic compartment | cell projection membrane | cytoplasmic vesicle | cell body | cell | nuclear lumen | neuronal cell body | distal axon | dendrite terminus | vacuolar lumen | ruffle membrane | cytoplasmic vesicle lumen | cytoplasm | endocytic vesicle lumen | intracellular organelle | dendritic tree | ficolin-1-rich granule lumen | leading edge membrane | melanosome | protein-containing complex | cell projection | secretory vesicle | endomembrane system | nucleoplasm | plasma membrane | cell leading edge | vacuole | vesicle | perinuclear region of cytoplasm | extracellular exosome | site of polarized growth | lytic vacuole | axonal growth cone | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | lysosome | extracellular space | cell periphery | axon | membrane-enclosed lumen | lysosomal lumen | growth cone | secretory granule lumen | cytosol | intracellular vesicle | dendritic growth cone | endocytic vesicle | intracellular | myelin sheath | membrane | vesicle lumen